KLF10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	25 studies	28% ± 11%	Explore
endothelial cell	24 studies	31% ± 13%	Explore
classical monocyte	21 studies	33% ± 16%	Explore
smooth muscle cell	15 studies	32% ± 13%	Explore
conventional dendritic cell	15 studies	37% ± 16%	Explore
pericyte	14 studies	32% ± 16%	Explore
basal cell	14 studies	25% ± 5%	Explore
macrophage	13 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	13 studies	26% ± 8%	Explore
plasmacytoid dendritic cell	13 studies	28% ± 12%	Explore
non-classical monocyte	12 studies	31% ± 9%	Explore
monocyte	10 studies	28% ± 8%	Explore
capillary endothelial cell	10 studies	25% ± 6%	Explore
myofibroblast cell	10 studies	30% ± 17%	Explore
endothelial cell of vascular tree	9 studies	28% ± 9%	Explore
connective tissue cell	8 studies	24% ± 7%	Explore
natural killer cell	7 studies	18% ± 3%	Explore
epithelial cell	7 studies	37% ± 21%	Explore
vein endothelial cell	7 studies	22% ± 6%	Explore
dendritic cell	6 studies	41% ± 15%	Explore
myeloid cell	6 studies	33% ± 13%	Explore
ciliated cell	6 studies	30% ± 16%	Explore
endothelial cell of artery	6 studies	23% ± 7%	Explore
type I pneumocyte	5 studies	32% ± 7%	Explore
mononuclear phagocyte	5 studies	19% ± 2%	Explore
memory B cell	5 studies	20% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	22% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	25% ± 8%	Explore
secretory cell	4 studies	28% ± 4%	Explore
hematopoietic precursor cell	3 studies	34% ± 15%	Explore
pancreatic A cell	3 studies	29% ± 17%	Explore
type B pancreatic cell	3 studies	36% ± 11%	Explore
plasmablast	3 studies	31% ± 10%	Explore
glomerular endothelial cell	3 studies	24% ± 3%	Explore
abnormal cell	3 studies	33% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 5%	Explore
hematopoietic stem cell	3 studies	34% ± 11%	Explore
mucosal invariant T cell	3 studies	24% ± 4%	Explore
naive B cell	3 studies	17% ± 1%	Explore
precursor B cell	3 studies	29% ± 15%	Explore
pro-B cell	3 studies	37% ± 16%	Explore
mesothelial cell	3 studies	38% ± 29%	Explore
innate lymphoid cell	3 studies	21% ± 3%	Explore
intermediate monocyte	3 studies	43% ± 16%	Explore
gamma-delta T cell	3 studies	25% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	28% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	24% ± 4%	Explore
peripheral blood	8 studies	22% ± 4%	Explore
uterus	5 studies	31% ± 10%	Explore
pancreas	3 studies	34% ± 15%	Explore
kidney	3 studies	22% ± 5%	Explore
skin	3 studies	26% ± 9%	Explore
breast	3 studies	25% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	7272.26	576 / 578	100%	71.22	1153 / 1155
intestine	99%	6749.19	961 / 966	99%	59.73	524 / 527
breast	100%	6383.32	458 / 459	99%	76.01	1107 / 1118
esophagus	99%	5308.26	1426 / 1445	100%	99.97	183 / 183
stomach	97%	5146.11	350 / 359	100%	70.29	285 / 286
thymus	99%	4035.17	647 / 653	97%	56.86	589 / 605
pancreas	96%	3925.95	316 / 328	98%	67.46	175 / 178
bladder	100%	3668.14	21 / 21	94%	52.38	474 / 504
kidney	98%	3408.92	87 / 89	96%	102.71	864 / 901
skin	99%	7408.87	1798 / 1809	93%	40.56	438 / 472
uterus	93%	3413.08	158 / 170	98%	72.73	449 / 459
adrenal gland	96%	3862.79	248 / 258	92%	59.39	212 / 230
prostate	91%	2616.97	223 / 245	89%	42.79	447 / 502
liver	88%	2612.98	200 / 226	86%	37.47	349 / 406
ovary	77%	3377.00	139 / 180	96%	50.51	411 / 430
tonsil	0%	0	0 / 0	100%	63.54	45 / 45
ureter	0%	0	0 / 0	100%	22.14	1 / 1
muscle	100%	13022.22	802 / 803	0%	0	0 / 0
spleen	100%	3961.85	240 / 241	0%	0	0 / 0
adipose	100%	7336.76	1199 / 1204	0%	0	0 / 0
blood vessel	97%	4359.58	1296 / 1335	0%	0	0 / 0
brain	13%	212.35	344 / 2642	83%	30.89	588 / 705
lymph node	0%	0	0 / 0	93%	32.35	27 / 29
heart	92%	2989.49	789 / 861	0%	0	0 / 0
peripheral blood	63%	2071.42	585 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	56%	12.08	45 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0009267	Biological process	cellular response to starvation
GO_0042752	Biological process	regulation of circadian rhythm
GO_0007267	Biological process	cell-cell signaling
GO_0007623	Biological process	circadian rhythm
GO_0045672	Biological process	positive regulation of osteoclast differentiation
GO_0030282	Biological process	bone mineralization
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001046	Molecular function	core promoter sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KLF10
Protein name	Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)
Synonyms	TIEG TIEG1
Description	FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. .
Accessions	ENST00000285407.11 [Q13118-1] Q13118 ENST00000395884.3 [Q13118-2]

KLF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review