Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 23% ± 4% | |
| astrocyte | 4 studies | 24% ± 6% | |
| microglial cell | 4 studies | 21% ± 3% | |
| endothelial cell | 3 studies | 19% ± 3% | |
| regulatory T cell | 3 studies | 22% ± 7% | |
| GABAergic neuron | 3 studies | 40% ± 4% | |
| glutamatergic neuron | 3 studies | 47% ± 7% | |
| dendritic cell | 3 studies | 22% ± 3% | |
| oligodendrocyte | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 35% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 997.68 | 1445 / 1445 | 100% | 9.82 | 183 / 183 |
| ovary | 100% | 1235.72 | 180 / 180 | 100% | 9.96 | 430 / 430 |
| lung | 100% | 973.64 | 577 / 578 | 100% | 10.96 | 1155 / 1155 |
| breast | 100% | 994.83 | 459 / 459 | 100% | 10.76 | 1116 / 1118 |
| brain | 100% | 888.20 | 2637 / 2642 | 100% | 10.02 | 705 / 705 |
| intestine | 100% | 1148.95 | 966 / 966 | 100% | 10.48 | 526 / 527 |
| bladder | 100% | 1130.76 | 21 / 21 | 100% | 11.63 | 503 / 504 |
| prostate | 100% | 1258.52 | 245 / 245 | 100% | 7.77 | 501 / 502 |
| thymus | 100% | 1177.17 | 653 / 653 | 100% | 8.11 | 603 / 605 |
| stomach | 100% | 875.64 | 359 / 359 | 100% | 9.73 | 285 / 286 |
| uterus | 100% | 1327.16 | 170 / 170 | 100% | 13.91 | 457 / 459 |
| pancreas | 100% | 588.47 | 327 / 328 | 99% | 8.50 | 176 / 178 |
| kidney | 100% | 908.26 | 89 / 89 | 98% | 6.11 | 885 / 901 |
| skin | 100% | 1147.84 | 1809 / 1809 | 98% | 10.71 | 461 / 472 |
| adrenal gland | 100% | 861.01 | 258 / 258 | 96% | 6.38 | 221 / 230 |
| liver | 100% | 603.47 | 226 / 226 | 96% | 5.15 | 390 / 406 |
| adipose | 100% | 921.37 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 945.77 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 29.83 | 29 / 29 |
| spleen | 100% | 1465.42 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 10.93 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.92 | 1 / 1 |
| heart | 99% | 571.71 | 852 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 519.19 | 793 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 6.26 | 75 / 80 |
| peripheral blood | 83% | 1402.53 | 775 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0021510 | Biological process | spinal cord development |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0031507 | Biological process | heterochromatin formation |
| GO_0035098 | Cellular component | ESC/E(Z) complex |
| GO_0005694 | Cellular component | chromosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0031491 | Molecular function | nucleosome binding |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0042054 | Molecular function | histone methyltransferase activity |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042802 | Molecular function | identical protein binding |
| Gene name | EED |
| Protein name | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) Embryonic ectoderm development Alternative protein EED |
| Synonyms | |
| Description | FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. . |
| Accessions | ENST00000528180.5 ENST00000672825.1 [O75530-1] H0YEL4 A0A9L9PY60 O75530 ENST00000327320.8 [O75530-3] A0A5F9ZI63 ENST00000527888.1 L8E7I9 ENST00000707108.1 E9PMU3 ENST00000534595.1 ENST00000673233.2 ENST00000351625.10 [O75530-2] ENST00000263360.11 [O75530-1] E9PJK2 |
