ZNF93 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF93 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF93 at tissue level.

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameZNF93
Protein nameZNF93 protein
Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34)
Zinc finger protein 93
SynonymshCG_1775441
ZNF505
DescriptionFUNCTION: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 . Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression . .

AccessionsENST00000592160.5
ENST00000586021.5
K7EPV7
K7EQ36
ENST00000588146.1
K7ES58
P35789
Q6NS90
ENST00000591366.5
K7EPG7
ENST00000343769.6 [P35789-1]