SOX3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SOX3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	93.40	2514 / 2642	84%	13.01	595 / 705
adrenal gland	48%	14.28	125 / 258	5%	0.29	12 / 230
thymus	35%	14.52	228 / 653	12%	1.74	73 / 605
ovary	11%	3.15	20 / 180	12%	2.37	52 / 430
muscle	23%	10.51	184 / 803	0%	0	0 / 0
uterus	19%	23.36	32 / 170	3%	0.30	12 / 459
prostate	0%	0.07	1 / 245	3%	0.11	17 / 502
breast	1%	0.21	4 / 459	2%	0.14	25 / 1118
blood vessel	1%	0.28	20 / 1335	0%	0	0 / 0
lung	0%	0	0 / 578	1%	0.09	13 / 1155
kidney	0%	0	0 / 89	1%	0.06	8 / 901
adipose	1%	0.13	8 / 1204	0%	0	0 / 0
skin	0%	0.11	8 / 1809	0%	0.00	1 / 472
stomach	0%	0.08	1 / 359	0%	0.02	1 / 286
bladder	0%	0	0 / 21	0%	0.02	2 / 504
intestine	0%	0.02	1 / 966	0%	0.01	1 / 527
liver	0%	0	0 / 226	0%	0.01	1 / 406
heart	0%	0.04	2 / 861	0%	0	0 / 0
esophagus	0%	0.03	2 / 1445	0%	0	0 / 183
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
pancreas	0%	0	0 / 328	0%	0	0 / 178
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030182	Biological process	neuron differentiation
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0060324	Biological process	face development
GO_0007417	Biological process	central nervous system development
GO_0007420	Biological process	brain development
GO_0021983	Biological process	pituitary gland development
GO_0007530	Biological process	sex determination
GO_0021854	Biological process	hypothalamus development
GO_0007423	Biological process	sensory organ development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0005515	Molecular function	protein binding

Gene name	SOX3
Protein name	Transcription factor SOX-3
Synonyms
Description	FUNCTION: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). .
Accessions	P41225 ENST00000370536.5

SOX3 report