ZNF274 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005737Cellular componentcytoplasm
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameZNF274
Protein nameZinc finger protein 274
Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)
SynonymsZKSCAN19
SP2114
DescriptionFUNCTION: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions . .

AccessionsENST00000326804.8
ENST00000617501.5 [Q96GC6-1]
ENST00000424679.6 [Q96GC6-3]
M0QXW4
ENST00000345813.7 [Q96GC6-2]
ENST00000597528.1
ENST00000594839.5
Q96GC6
A0A0A0MR47
M0QY30
ENST00000610905.4 [Q96GC6-1]