MAFB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0021599Biological processabducens nerve formation
GO_0045637Biological processregulation of myeloid cell differentiation
GO_0045647Biological processnegative regulation of erythrocyte differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021571Biological processrhombomere 5 development
GO_0016485Biological processprotein processing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0033077Biological processT cell differentiation in thymus
GO_1903575Biological processcornified envelope assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048538Biological processthymus development
GO_0007379Biological processsegment specification
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042472Biological processinner ear morphogenesis
GO_0035284Biological processbrain segmentation
GO_0021572Biological processrhombomere 6 development
GO_0007423Biological processsensory organ development
GO_0140467Biological processintegrated stress response signaling
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAFB
Protein nameAlternative protein MAFB
Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)
SynonymsKRML
DescriptionFUNCTION: Acts as a transcriptional activator or repressor . Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). .

AccessionsQ9Y5Q3
ENST00000373313.3
L8ECC4