DDX20 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DDX20 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0000244Biological processspliceosomal tri-snRNP complex assembly
GO_0000387Biological processspliceosomal snRNP assembly
GO_0006396Biological processRNA processing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050810Biological processregulation of steroid biosynthetic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048477Biological processoogenesis
GO_0005856Cellular componentcytoskeleton
GO_0032797Cellular componentSMN complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0034719Cellular componentSMN-Sm protein complex
GO_0090571Cellular componentRNA polymerase II transcription repressor complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097504Cellular componentGemini of coiled bodies
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003724Molecular functionRNA helicase activity
GO_0003729Molecular functionmRNA binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameDDX20
Protein nameProbable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3)
RNA helicase (EC 3.6.4.13)
SynonymsGEMIN3
DP103
DescriptionFUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). .

AccessionsENST00000680383.1
A0A7P0T8G7
ENST00000681559.1
Q8IYV2
ENST00000680518.1
ENST00000680627.1
A0A7P0Z4K8
A0A7P0TBA6
ENST00000679576.1
A0A7P0Z4I9
A0A7P0TB94
ENST00000680936.1
ENST00000369702.5 [Q9UHI6-1]
Q8NEH0
A0A7P0T9T8
Q8TDR3
ENST00000679724.1 [Q9UHI6-1]
ENST00000533164.6 [Q9UHI6-2]
Q9UHI6