NANOG report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NANOG at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NANOG at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045595Biological processregulation of cell differentiation
GO_0030154Biological processcell differentiation
GO_0019827Biological processstem cell population maintenance
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001714Biological processendodermal cell fate specification
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNANOG
Protein nameNANOG
Nanog homeobox
Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)
Synonyms
DescriptionFUNCTION: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter . Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. .

AccessionsQ9H9S0
J7H4F6
ENST00000229307.9 [Q9H9S0-1]
J7HA22
ENST00000541267.5
F5GZI2
J7H4A9
J7HA98
ENST00000526286.1 [Q9H9S0-2]