SATB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0001764Biological processneuron migration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0009880Biological processembryonic pattern specification
GO_0060021Biological processroof of mouth development
GO_0002076Biological processosteoblast development
GO_0051216Biological processcartilage development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0000118Cellular componenthistone deacetylase complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSATB2
Protein nameSATB homeobox 2
DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)
DNA-binding protein SATB (Special AT-rich sequence-binding protein)
SynonymsKIAA1034
DescriptionFUNCTION: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. .

AccessionsENST00000260926.9 [Q9UPW6-1]
A0A8V8TPF3
ENST00000428695.6 [Q9UPW6-2]
ENST00000700193.1 [Q9UPW6-1]
ENST00000440919.1
ENST00000700191.1 [Q9UPW6-2]
ENST00000700208.1
C9JR56
ENST00000417098.6 [Q9UPW6-1]
F8WCV6
Q9UPW6
A0A8V8TR16
ENST00000700210.1
ENST00000457245.5 [Q9UPW6-1]
ENST00000443023.5