THAP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of THAP1 at tissue level.

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006351Biological processDNA-templated transcription
GO_0001935Biological processendothelial cell proliferation
GO_0007346Biological processregulation of mitotic cell cycle
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0016605Cellular componentPML body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHAP1
Protein nameTHAP domain-containing protein 1
Synonyms
DescriptionFUNCTION: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. .

FUNCTION: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes. .

AccessionsQ9NVV9
ENST00000345117.2 [Q9NVV9-2]
ENST00000254250.7 [Q9NVV9-1]
E9PIS9
ENST00000529779.1