KAT2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0106227Biological processpeptidyl-lysine glutarylation
GO_0045995Biological processregulation of embryonic development
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0001701Biological processin utero embryonic development
GO_0048312Biological processintracellular distribution of mitochondria
GO_0007507Biological processheart development
GO_0007616Biological processlong-term memory
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090043Biological processregulation of tubulin deacetylation
GO_0006282Biological processregulation of DNA repair
GO_0060173Biological processlimb development
GO_2000727Biological processpositive regulation of cardiac muscle cell differentiation
GO_0014070Biological processresponse to organic cyclic compound
GO_0018393Biological processinternal peptidyl-lysine acetylation
GO_0035264Biological processmulticellular organism growth
GO_2000036Biological processregulation of stem cell population maintenance
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0031346Biological processpositive regulation of cell projection organization
GO_0051302Biological processregulation of cell division
GO_0022037Biological processmetencephalon development
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0031667Biological processresponse to nutrient levels
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0048167Biological processregulation of synaptic plasticity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045589Biological processregulation of regulatory T cell differentiation
GO_0006094Biological processgluconeogenesis
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0046600Biological processnegative regulation of centriole replication
GO_0048144Biological processfibroblast proliferation
GO_0001756Biological processsomitogenesis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001843Biological processneural tube closure
GO_0050863Biological processregulation of T cell activation
GO_0061035Biological processregulation of cartilage development
GO_0043484Biological processregulation of RNA splicing
GO_1903010Biological processregulation of bone development
GO_0001819Biological processpositive regulation of cytokine production
GO_0030901Biological processmidbrain development
GO_0051726Biological processregulation of cell cycle
GO_0031647Biological processregulation of protein stability
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0021537Biological processtelencephalon development
GO_0005615Cellular componentextracellular space
GO_0072686Cellular componentmitotic spindle
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0045252Cellular componentoxoglutarate dehydrogenase complex
GO_0140672Cellular componentATAC complex
GO_0000124Cellular componentSAGA complex
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0106078Molecular functionhistone succinyltransferase activity
GO_0061733Molecular functionpeptide-lysine-N-acetyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0010484Molecular functionhistone H3 acetyltransferase activity
GO_0106229Molecular functionhistone glutaryltransferase activity
GO_0043992Molecular functionhistone H3K9 acetyltransferase activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0043993Molecular functionhistone H3K18 acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameKAT2A
Protein nameLysine acetyltransferase 2A
Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)
SynonymsGCN5L2
GCN5
DescriptionFUNCTION: Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context . Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes . Succinylation of histones gives a specific tag for epigenetic transcription activation . Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation . In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase . Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles . Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) . Acetylation of histones gives a specific tag for epigenetic transcription activation . Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes . Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PPARGC1A, PLK4 and TBX5 . Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 . Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 . Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A . Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes . .; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. .

AccessionsQ92830
ENST00000225916.10 [Q92830-1]
K7EPC4
K7ERS6
ENST00000465682.5
ENST00000588759.1