ORC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006270Biological processDNA replication initiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000808Cellular componentorigin recognition complex
GO_0000792Cellular componentheterochromatin
GO_0005664Cellular componentnuclear origin of replication recognition complex
GO_0005813Cellular componentcentrosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0000939Cellular componentinner kinetochore
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003688Molecular functionDNA replication origin binding

IV. Literature review

[source]
Gene nameORC2
Protein nameOrigin recognition complex subunit 2
SynonymsORC2L
DescriptionFUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. .

AccessionsENST00000234296.7
Q13416
C9JK08
ENST00000457595.1
ENST00000410039.5
B8ZZ80