FNIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0006468Biological processprotein phosphorylation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0001932Biological processregulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_1990877Cellular componentFNIP-folliculin RagC/D GAP
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0034451Cellular componentcentriolar satellite
GO_0005765Cellular componentlysosomal membrane
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0042030Molecular functionATPase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFNIP2
Protein nameFolliculin interacting protein 2
Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)
SynonymsFNIPL
KIAA1450
MAPO1
DescriptionFUNCTION: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 . Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 . Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 . Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy . In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 . Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 . Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). .

AccessionsH0Y8F3
D6RFH5
ENST00000512986.5
ENST00000264433.11 [Q9P278-1]
ENST00000504715.1
Q9P278