SIRT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000183Biological processrDNA heterochromatin formation
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0071872Biological processcellular response to epinephrine stimulus
GO_0051301Biological processcell division
GO_0042325Biological processregulation of phosphorylation
GO_0070446Biological processnegative regulation of oligodendrocyte progenitor proliferation
GO_0051775Biological processresponse to redox state
GO_0007084Biological processmitotic nuclear membrane reassembly
GO_0006914Biological processautophagy
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0051726Biological processregulation of cell cycle
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0031641Biological processregulation of myelination
GO_0051781Biological processpositive regulation of cell division
GO_0044546Biological processNLRP3 inflammasome complex assembly
GO_0045087Biological processinnate immune response
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0043687Biological processpost-translational protein modification
GO_0031507Biological processheterochromatin formation
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0045843Biological processnegative regulation of striated muscle tissue development
GO_0040029Biological processepigenetic regulation of gene expression
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0090042Biological processtubulin deacetylation
GO_0006476Biological processprotein deacetylation
GO_0007096Biological processregulation of exit from mitosis
GO_0031509Biological processsubtelomeric heterochromatin formation
GO_0034599Biological processcellular response to oxidative stress
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_0043388Biological processpositive regulation of DNA binding
GO_0061433Biological processcellular response to caloric restriction
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0044242Biological processcellular lipid catabolic process
GO_1900195Biological processpositive regulation of oocyte maturation
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0051987Biological processpositive regulation of attachment of spindle microtubules to kinetochore
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0022011Biological processmyelination in peripheral nervous system
GO_0051321Biological processmeiotic cell cycle
GO_0045836Biological processpositive regulation of meiotic nuclear division
GO_0021762Biological processsubstantia nigra development
GO_1902725Biological processnegative regulation of satellite cell differentiation
GO_0010507Biological processnegative regulation of autophagy
GO_0071456Biological processcellular response to hypoxia
GO_0044224Cellular componentjuxtaparanode region of axon
GO_0072687Cellular componentmeiotic spindle
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0043219Cellular componentlateral loop
GO_0072686Cellular componentmitotic spindle
GO_0005814Cellular componentcentriole
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0005739Cellular componentmitochondrion
GO_0000792Cellular componentheterochromatin
GO_0043204Cellular componentperikaryon
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0097386Cellular componentglial cell projection
GO_0000781Cellular componentchromosome, telomeric region
GO_0043209Cellular componentmyelin sheath
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005677Cellular componentchromatin silencing complex
GO_0043220Cellular componentSchmidt-Lanterman incisure
GO_0005829Cellular componentcytosol
GO_0033010Cellular componentparanodal junction
GO_0030426Cellular componentgrowth cone
GO_0033270Cellular componentparanode region of axon
GO_0005819Cellular componentspindle
GO_0008134Molecular functiontranscription factor binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0046970Molecular functionNAD-dependent histone H4K16 deacetylase activity
GO_0008270Molecular functionzinc ion binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0043130Molecular functionubiquitin binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0004407Molecular functionhistone deacetylase activity
GO_0042903Molecular functiontubulin deacetylase activity
GO_0017136Molecular functionNAD-dependent histone deacetylase activity
GO_0070403Molecular functionNAD+ binding
GO_0034979Molecular functionNAD-dependent protein lysine deacetylase activity
GO_0140773Molecular functionNAD-dependent protein demyristoylase activity
GO_0005515Molecular functionprotein binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0140774Molecular functionNAD-dependent protein depalmitoylase activity

IV. Literature review

[source]
Gene nameSIRT2
Protein nameSirtuin 2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
NAD-dependent protein deacetylase sirtuin-2 (NAD-dependent protein defatty-acylase sirtuin-2) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
SynonymsSIR2L
SIR2L2
DescriptionFUNCTION: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors . Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy . Plays a major role in the control of cell cycle progression and genomic stability . Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes . Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis . Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes . Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis . Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression . Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response . Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition . Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection . During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function . Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis . Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells . Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation . Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination . Involved in several cellular metabolic pathways . Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability . Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage . Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis . Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity . Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells . Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy . Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia . Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation . Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 . Deacetylates also EIF5A . Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions . Plays a role as tumor suppressor . In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes . .; FUNCTION: [Isoform 1]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. .; FUNCTION: [Isoform 2]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. .; FUNCTION: [Isoform 5]: Lacks deacetylation activity, at least toward known SIRT2 targets. .

AccessionsENST00000443898.5
ENST00000423526.5
ENST00000420440.5
E7EWX6
F8WBT6
C9JZQ0
ENST00000381766.8
ENST00000451193.5
Q8IXJ6
F8WDM4
C9J3U7
ENST00000392081.6 [Q8IXJ6-2]
B5MCS1
ENST00000249396.12 [Q8IXJ6-1]
F8WCF4
ENST00000414941.5
F8WF57
ENST00000358931.9
ENST00000407552.5
C9JR33
A0A0A0MRF5
ENST00000634533.2 [Q8IXJ6-1]
ENST00000447739.1
ENST00000437828.5
ENST00000635478.1 [Q8IXJ6-2]