WWC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032386Biological processregulation of intracellular transport
GO_0035330Biological processregulation of hippo signaling
GO_0035329Biological processhippo signaling
GO_0046621Biological processnegative regulation of organ growth
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035331Biological processnegative regulation of hippo signaling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0016477Biological processcell migration
GO_0032587Cellular componentruffle membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0060090Molecular functionmolecular adaptor activity
GO_0019900Molecular functionkinase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWWC1
Protein nameAlternative protein WWC1
WW and C2 domain containing 1
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)
SynonymsKIAA0869
DescriptionFUNCTION: Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway . Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway . Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway . Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation . Regulates collagen-stimulated activation of the ERK/MAPK cascade . Modulates directional migration of podocytes . Plays a role in cognition and memory performance . Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). .

AccessionsENST00000521089.5 [Q8IX03-2]
ENST00000524038.5
H0YAU4
L8E9S6
Q8IX03
ENST00000265293.9 [Q8IX03-1]
H0YBE8
ENST00000524228.5
H3BLZ3
ENST00000393895.7