Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 18 studies | 40% ± 22% | |
ciliated cell | 10 studies | 32% ± 14% | |
type I pneumocyte | 9 studies | 36% ± 15% | |
retinal cone cell | 7 studies | 54% ± 23% | |
glutamatergic neuron | 6 studies | 39% ± 21% | |
epithelial cell | 6 studies | 42% ± 21% | |
type II pneumocyte | 6 studies | 43% ± 12% | |
endothelial cell | 5 studies | 33% ± 10% | |
mesothelial cell | 5 studies | 34% ± 9% | |
club cell | 5 studies | 42% ± 13% | |
cholangiocyte | 4 studies | 52% ± 23% | |
hepatocyte | 4 studies | 41% ± 32% | |
interneuron | 4 studies | 33% ± 12% | |
retinal pigment epithelial cell | 4 studies | 35% ± 6% | |
GABAergic neuron | 4 studies | 35% ± 11% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 4% | |
ependymal cell | 3 studies | 57% ± 16% | |
basal cell | 3 studies | 24% ± 7% | |
kidney loop of Henle epithelial cell | 3 studies | 23% ± 8% | |
mucus secreting cell | 3 studies | 42% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 8560.29 | 89 / 89 | 99% | 47.84 | 890 / 901 |
pancreas | 100% | 3037.09 | 328 / 328 | 97% | 21.03 | 172 / 178 |
brain | 99% | 3992.41 | 2607 / 2642 | 97% | 23.88 | 687 / 705 |
prostate | 91% | 3198.96 | 222 / 245 | 100% | 46.24 | 502 / 502 |
lung | 98% | 3678.10 | 566 / 578 | 91% | 15.44 | 1050 / 1155 |
thymus | 100% | 4044.96 | 651 / 653 | 88% | 31.12 | 531 / 605 |
liver | 99% | 3064.09 | 223 / 226 | 79% | 15.08 | 319 / 406 |
stomach | 75% | 2936.14 | 270 / 359 | 95% | 17.20 | 273 / 286 |
breast | 59% | 1867.15 | 273 / 459 | 99% | 23.30 | 1102 / 1118 |
esophagus | 44% | 1237.13 | 641 / 1445 | 96% | 18.48 | 175 / 183 |
intestine | 37% | 629.82 | 362 / 966 | 97% | 16.44 | 510 / 527 |
bladder | 33% | 414.48 | 7 / 21 | 90% | 13.81 | 454 / 504 |
skin | 95% | 2795.57 | 1710 / 1809 | 24% | 2.39 | 114 / 472 |
ovary | 6% | 43.75 | 10 / 180 | 99% | 28.21 | 424 / 430 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.51 | 1 / 1 |
uterus | 8% | 117.54 | 13 / 170 | 84% | 15.80 | 384 / 459 |
tonsil | 0% | 0 | 0 / 0 | 80% | 7.89 | 36 / 45 |
eye | 0% | 0 | 0 / 0 | 36% | 2.86 | 29 / 80 |
adipose | 29% | 599.61 | 349 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 28% | 3.21 | 8 / 29 |
heart | 8% | 95.28 | 67 / 861 | 0% | 0 | 0 / 0 |
adrenal gland | 2% | 16.23 | 5 / 258 | 4% | 0.38 | 9 / 230 |
peripheral blood | 3% | 20.96 | 26 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 1% | 9.64 | 10 / 1335 | 0% | 0 | 0 / 0 |
spleen | 0% | 2.88 | 1 / 241 | 0% | 0 | 0 / 0 |
muscle | 0% | 1.69 | 2 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030010 | Biological process | establishment of cell polarity |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0032386 | Biological process | regulation of intracellular transport |
GO_0035330 | Biological process | regulation of hippo signaling |
GO_0035329 | Biological process | hippo signaling |
GO_0046621 | Biological process | negative regulation of organ growth |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0035331 | Biological process | negative regulation of hippo signaling |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0016477 | Biological process | cell migration |
GO_0032587 | Cellular component | ruffle membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0019900 | Molecular function | kinase binding |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | WWC1 |
Protein name | Alternative protein WWC1 WW and C2 domain containing 1 Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) |
Synonyms | KIAA0869 |
Description | FUNCTION: Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway . Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway . Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway . Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation . Regulates collagen-stimulated activation of the ERK/MAPK cascade . Modulates directional migration of podocytes . Plays a role in cognition and memory performance . Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). . |
Accessions | ENST00000521089.5 [Q8IX03-2] ENST00000524038.5 H0YAU4 L8E9S6 Q8IX03 ENST00000265293.9 [Q8IX03-1] H0YBE8 ENST00000524228.5 H3BLZ3 ENST00000393895.7 |