ZGLP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZGLP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZGLP1 at tissue level.

III. Associated gene sets

GO_0048599Biological processoocyte development
GO_0007283Biological processspermatogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0008270Molecular functionzinc ion binding
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameZGLP1
Protein nameGATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1)
Zinc finger GATA like protein 1
SynonymsGLP1
DescriptionFUNCTION: Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase. .

AccessionsA0A9L9PXT6
P0C6A0
ENST00000707000.1
ENST00000403903.7
B5MCP8
ENST00000403352.1