DLG1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	41% ± 18%	Explore
astrocyte	19 studies	42% ± 17%	Explore
oligodendrocyte	17 studies	75% ± 19%	Explore
microglial cell	14 studies	42% ± 16%	Explore
glutamatergic neuron	13 studies	61% ± 26%	Explore
oligodendrocyte precursor cell	13 studies	53% ± 19%	Explore
fibroblast	13 studies	38% ± 14%	Explore
endothelial cell of lymphatic vessel	12 studies	42% ± 20%	Explore
ciliated cell	11 studies	36% ± 14%	Explore
epithelial cell	11 studies	41% ± 23%	Explore
macrophage	11 studies	33% ± 15%	Explore
smooth muscle cell	10 studies	31% ± 14%	Explore
GABAergic neuron	10 studies	44% ± 22%	Explore
pericyte	10 studies	33% ± 12%	Explore
basal cell	9 studies	44% ± 19%	Explore
adipocyte	9 studies	57% ± 11%	Explore
type I pneumocyte	8 studies	39% ± 18%	Explore
neuron	8 studies	43% ± 24%	Explore
mast cell	8 studies	25% ± 8%	Explore
B cell	7 studies	26% ± 7%	Explore
myeloid cell	7 studies	24% ± 7%	Explore
club cell	7 studies	36% ± 16%	Explore
interneuron	6 studies	42% ± 18%	Explore
retinal cone cell	6 studies	40% ± 20%	Explore
dendritic cell	6 studies	26% ± 5%	Explore
mesothelial cell	6 studies	36% ± 11%	Explore
Mueller cell	6 studies	59% ± 26%	Explore
type II pneumocyte	6 studies	38% ± 12%	Explore
goblet cell	6 studies	31% ± 24%	Explore
CD4-positive, alpha-beta T cell	5 studies	25% ± 4%	Explore
cardiac muscle cell	5 studies	46% ± 11%	Explore
lymphocyte	5 studies	29% ± 12%	Explore
T cell	5 studies	32% ± 8%	Explore
monocyte	5 studies	31% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
glial cell	4 studies	38% ± 13%	Explore
granule cell	4 studies	51% ± 17%	Explore
plasma cell	4 studies	37% ± 4%	Explore
retinal pigment epithelial cell	4 studies	45% ± 26%	Explore
CD8-positive, alpha-beta T cell	4 studies	23% ± 3%	Explore
retina horizontal cell	4 studies	21% ± 7%	Explore
retinal rod cell	4 studies	57% ± 15%	Explore
respiratory goblet cell	4 studies	42% ± 16%	Explore
natural killer cell	4 studies	27% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	21% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
non-classical monocyte	3 studies	20% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	67% ± 9%	Explore
GABAergic interneuron	3 studies	36% ± 3%	Explore
progenitor cell	3 studies	37% ± 13%	Explore
squamous epithelial cell	3 studies	42% ± 20%	Explore
mononuclear phagocyte	3 studies	25% ± 8%	Explore
vein endothelial cell	3 studies	31% ± 12%	Explore
OFF-bipolar cell	3 studies	37% ± 15%	Explore
amacrine cell	3 studies	31% ± 11%	Explore
glycinergic amacrine cell	3 studies	29% ± 6%	Explore
secretory cell	3 studies	28% ± 11%	Explore
endothelial cell of vascular tree	3 studies	36% ± 16%	Explore
hepatocyte	3 studies	68% ± 17%	Explore
connective tissue cell	3 studies	35% ± 17%	Explore
ependymal cell	3 studies	53% ± 16%	Explore
enteroendocrine cell	3 studies	18% ± 3%	Explore
alveolar macrophage	3 studies	40% ± 9%	Explore
leukocyte	3 studies	45% ± 9%	Explore
transit amplifying cell	3 studies	44% ± 37%	Explore
mucus secreting cell	3 studies	44% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	57% ± 20%	Explore
lung	9 studies	31% ± 11%	Explore
eye	6 studies	45% ± 19%	Explore
heart	5 studies	33% ± 10%	Explore
peripheral blood	3 studies	23% ± 3%	Explore
liver	3 studies	45% ± 22%	Explore
intestine	3 studies	21% ± 3%	Explore
adipose	3 studies	44% ± 16%	Explore
kidney	3 studies	33% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	6241.62	2642 / 2642	100%	15.66	705 / 705
esophagus	100%	4853.51	1445 / 1445	100%	27.48	183 / 183
lung	100%	3079.19	577 / 578	100%	19.94	1154 / 1155
breast	100%	3223.91	459 / 459	100%	17.58	1114 / 1118
prostate	100%	3049.99	245 / 245	100%	12.75	500 / 502
ovary	100%	3293.77	180 / 180	100%	13.18	428 / 430
intestine	100%	4089.17	966 / 966	99%	14.10	524 / 527
uterus	100%	3473.19	170 / 170	99%	19.72	456 / 459
bladder	100%	3546.57	21 / 21	99%	14.72	500 / 504
thymus	100%	4847.67	653 / 653	99%	16.89	600 / 605
kidney	100%	2934.45	89 / 89	99%	14.09	891 / 901
stomach	100%	3221.40	359 / 359	98%	15.26	281 / 286
pancreas	99%	1656.19	324 / 328	99%	12.14	176 / 178
adrenal gland	100%	2803.90	258 / 258	94%	9.82	216 / 230
skin	100%	4307.58	1808 / 1809	91%	10.21	430 / 472
liver	100%	2169.40	226 / 226	89%	7.00	361 / 406
blood vessel	100%	3468.97	1335 / 1335	0%	0	0 / 0
muscle	100%	3353.37	803 / 803	0%	0	0 / 0
spleen	100%	2241.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.88	45 / 45
ureter	0%	0	0 / 0	100%	4.79	1 / 1
adipose	100%	3163.71	1203 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	9.03	28 / 29
heart	93%	2473.36	803 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	63%	4.78	50 / 80
peripheral blood	38%	1056.92	355 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009790	Biological process	embryo development
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_1901222	Biological process	regulation of non-canonical NF-kappaB signal transduction
GO_0072659	Biological process	protein localization to plasma membrane
GO_0042391	Biological process	regulation of membrane potential
GO_0042098	Biological process	T cell proliferation
GO_0048704	Biological process	embryonic skeletal system morphogenesis
GO_0030041	Biological process	actin filament polymerization
GO_0043113	Biological process	receptor clustering
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042982	Biological process	amyloid precursor protein metabolic process
GO_0051660	Biological process	establishment of centrosome localization
GO_1903760	Biological process	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO_0031641	Biological process	regulation of myelination
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0007163	Biological process	establishment or maintenance of cell polarity
GO_0099072	Biological process	regulation of postsynaptic membrane neurotransmitter receptor levels
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0060022	Biological process	hard palate development
GO_0048608	Biological process	reproductive structure development
GO_0031579	Biological process	membrane raft organization
GO_0048745	Biological process	smooth muscle tissue development
GO_1903764	Biological process	regulation of potassium ion export across plasma membrane
GO_0046037	Biological process	GMP metabolic process
GO_0001771	Biological process	immunological synapse formation
GO_0043622	Biological process	cortical microtubule organization
GO_1903286	Biological process	regulation of potassium ion import
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0007268	Biological process	chemical synaptic transmission
GO_0070830	Biological process	bicellular tight junction assembly
GO_1902473	Biological process	regulation of protein localization to synapse
GO_0043268	Biological process	positive regulation of potassium ion transport
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0098911	Biological process	regulation of ventricular cardiac muscle cell action potential
GO_1902305	Biological process	regulation of sodium ion transmembrane transport
GO_0031503	Biological process	protein-containing complex localization
GO_0030432	Biological process	peristalsis
GO_0097120	Biological process	receptor localization to synapse
GO_0099562	Biological process	maintenance of postsynaptic density structure
GO_0046710	Biological process	GDP metabolic process
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0001935	Biological process	endothelial cell proliferation
GO_0007015	Biological process	actin filament organization
GO_0002088	Biological process	lens development in camera-type eye
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0008360	Biological process	regulation of cell shape
GO_0030953	Biological process	astral microtubule organization
GO_0098609	Biological process	cell-cell adhesion
GO_0030866	Biological process	cortical actin cytoskeleton organization
GO_0099645	Biological process	neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0045197	Biological process	establishment or maintenance of epithelial cell apical/basal polarity
GO_1903753	Biological process	negative regulation of p38MAPK cascade
GO_0001772	Cellular component	immunological synapse
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0045121	Cellular component	membrane raft
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043005	Cellular component	neuron projection
GO_0035748	Cellular component	myelin sheath abaxonal region
GO_0005923	Cellular component	bicellular tight junction
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0043219	Cellular component	lateral loop
GO_0097060	Cellular component	synaptic membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005912	Cellular component	adherens junction
GO_0031253	Cellular component	cell projection membrane
GO_0014704	Cellular component	intercalated disc
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0097025	Cellular component	MPP7-DLG1-LIN7 complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016328	Cellular component	lateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0033268	Cellular component	node of Ranvier
GO_0016324	Cellular component	apical plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0042383	Cellular component	sarcolemma
GO_0005911	Cellular component	cell-cell junction
GO_0005829	Cellular component	cytosol
GO_0005604	Cellular component	basement membrane
GO_0030054	Cellular component	cell junction
GO_0004385	Molecular function	guanylate kinase activity
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0098919	Molecular function	structural constituent of postsynaptic density
GO_0004721	Molecular function	phosphoprotein phosphatase activity
GO_0060090	Molecular function	molecular adaptor activity
GO_0019902	Molecular function	phosphatase binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0015459	Molecular function	potassium channel regulator activity
GO_0035255	Molecular function	ionotropic glutamate receptor binding
GO_0097016	Molecular function	L27 domain binding

IV. Literature review

[source]

Gene name	DLG1
Protein name	Discs, large homolog 1 (Drosophila) transcript variant 6-v1 Discs large MAGUK scaffold protein 1 Discs, large homolog 1 (Drosophila) transcript variant 6-v2 Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Disks large homolog 1 Alternative protein DLG1
Synonyms
Description	FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane . .
Accessions	A0A590UJS9 A0A590UJ25 A0A0C4DFT3 ENST00000657381.1 ENST00000661453.1 [Q12959-3] A0A590UJX2 ENST00000671246.1 ENST00000661013.1 ENST00000666007.1 [Q12959-5] A0A590UJZ4 A0A590UJ64 ENST00000671185.1 [Q12959-3] A0A590UJ08 ENST00000443183.5 [Q12959-9] C9J110 Q6PJH1 A0A590UJR5 A0A590UK52 A0A590UK70 ENST00000665728.1 A0A590UK13 ENST00000346964.6 [Q12959-2] C9JCP6 A0A590UK31 ENST00000670935.1 [Q12959-1] ENST00000659716.1 [Q12959-3] ENST00000419553.6 A0A590UJE6 A0A590UK48 A8MUT6 ENST00000419354.5 [Q12959-1] ENST00000450955.5 [Q12959-4] A0A3G9CMW0 ENST00000669332.1 ENST00000392382.6 [Q12959-3] E7EQD7 ENST00000447466.1 ENST00000664991.1 ENST00000419227.5 ENST00000660237.1 A0A590UK02 ENST00000660898.1 ENST00000661229.1 B4E2H8 ENST00000412364.2 A0A590UJ86 ENST00000662727.1 F2Z2L0 A0A590UJ68 ENST00000660432.1 A0A590UK81 ENST00000654733.1 ENST00000659221.1 ENST00000658701.1 ENST00000653795.1 L8E7Z2 ENST00000667104.1 ENST00000392381.7 ENST00000657098.1 H7C166 ENST00000661336.1 ENST00000392380.6 ENST00000663148.1 [Q12959-3] ENST00000434148.1 ENST00000658155.1 ENST00000660553.1 A0A590UJL2 ENST00000661440.1 A0A3G9CMV0 ENST00000669565.1 [Q12959-4] C9IYP1 ENST00000656428.1 ENST00000670455.1 [Q12959-4] A0A590UJD9 A0A590UKA8 ENST00000656087.1 C9JN61 C9JUA9 A0A590UJ18 ENST00000669714.1 ENST00000654737.1 ENST00000448528.6 [Q12959-1] A0A590UJ81 ENST00000670366.1 ENST00000653331.1 ENST00000436682.6 A0A590UJ95 Q12959 ENST00000667157.1 [Q12959-4] A0A590UJC5 ENST00000456699.6 ENST00000655488.1 [Q12959-3] ENST00000422288.6 [Q12959-5] ENST00000357674.9 [Q12959-4] ENST00000469073.2 A0A590UJ29 ENST00000661808.1 ENST00000452595.5 [Q12959-8] A0A590UJR4 ENST00000664564.1 ENST00000453607.5 ENST00000656944.1 ENST00000667971.1

DLG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review