TPR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010793Biological processregulation of mRNA export from nucleus
GO_0006405Biological processRNA export from nucleus
GO_0046832Biological processnegative regulation of RNA export from nucleus
GO_0035457Biological processcellular response to interferon-alpha
GO_0006611Biological processprotein export from nucleus
GO_0006999Biological processnuclear pore organization
GO_0034605Biological processcellular response to heat
GO_0070849Biological processresponse to epidermal growth factor
GO_0031453Biological processpositive regulation of heterochromatin formation
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0032880Biological processregulation of protein localization
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0051292Biological processnuclear pore complex assembly
GO_0051301Biological processcell division
GO_0031990Biological processmRNA export from nucleus in response to heat stress
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006406Biological processmRNA export from nucleus
GO_0043578Biological processnuclear matrix organization
GO_0045947Biological processnegative regulation of translational initiation
GO_0006606Biological processprotein import into nucleus
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0010965Biological processregulation of mitotic sister chromatid separation
GO_0006913Biological processnucleocytoplasmic transport
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0046825Biological processregulation of protein export from nucleus
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0006404Biological processRNA import into nucleus
GO_0042306Biological processregulation of protein import into nucleus
GO_0031647Biological processregulation of protein stability
GO_0042405Cellular componentnuclear inclusion body
GO_0005643Cellular componentnuclear pore
GO_0072686Cellular componentmitotic spindle
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005868Cellular componentcytoplasmic dynein complex
GO_0005635Cellular componentnuclear envelope
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0034399Cellular componentnuclear periphery
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0003682Molecular functionchromatin binding
GO_0015631Molecular functiontubulin binding
GO_0031072Molecular functionheat shock protein binding
GO_0017056Molecular functionstructural constituent of nuclear pore
GO_0003729Molecular functionmRNA binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0003723Molecular functionRNA binding
GO_0070840Molecular functiondynein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTPR
Protein nameTPR protein
Translocated promoter region, nuclear basket protein
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
Synonyms
DescriptionFUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export . Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. .

AccessionsQ504U6
ENST00000613151.1 [P12270-2]
A0PJC9
Q5SWX9
Q58F23
ENST00000451586.1
P12270
ENST00000367478.9 [P12270-1]
Q9UE33