SUZ12 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	27% ± 8%	Explore
natural killer cell	10 studies	20% ± 4%	Explore
astrocyte	10 studies	29% ± 14%	Explore
B cell	9 studies	24% ± 6%	Explore
oligodendrocyte	9 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
microglial cell	8 studies	25% ± 9%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 15%	Explore
GABAergic neuron	7 studies	36% ± 19%	Explore
glutamatergic neuron	7 studies	41% ± 23%	Explore
epithelial cell	7 studies	37% ± 16%	Explore
macrophage	7 studies	25% ± 7%	Explore
naive B cell	6 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	6 studies	22% ± 7%	Explore
dendritic cell	6 studies	26% ± 12%	Explore
fibroblast	6 studies	21% ± 6%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 5%	Explore
hematopoietic precursor cell	5 studies	29% ± 12%	Explore
neuron	5 studies	30% ± 13%	Explore
basal cell	5 studies	26% ± 11%	Explore
club cell	5 studies	21% ± 7%	Explore
regulatory T cell	5 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	5 studies	22% ± 7%	Explore
interneuron	5 studies	38% ± 26%	Explore
T cell	4 studies	20% ± 2%	Explore
plasmablast	4 studies	40% ± 12%	Explore
leukocyte	4 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	20% ± 4%	Explore
mature NK T cell	4 studies	18% ± 2%	Explore
myeloid cell	4 studies	25% ± 7%	Explore
retinal cone cell	4 studies	30% ± 3%	Explore
adipocyte	4 studies	20% ± 6%	Explore
ciliated cell	4 studies	30% ± 9%	Explore
type II pneumocyte	4 studies	21% ± 6%	Explore
classical monocyte	3 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	23% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
retinal bipolar neuron	3 studies	23% ± 4%	Explore
progenitor cell	3 studies	19% ± 4%	Explore
retina horizontal cell	3 studies	23% ± 3%	Explore
retinal rod cell	3 studies	17% ± 1%	Explore
lymphocyte	3 studies	27% ± 5%	Explore
rod bipolar cell	3 studies	28% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 2%	Explore
type I pneumocyte	3 studies	23% ± 6%	Explore
monocyte	3 studies	22% ± 4%	Explore
enteroendocrine cell	3 studies	18% ± 2%	Explore
myofibroblast cell	3 studies	24% ± 5%	Explore
pericyte	3 studies	21% ± 5%	Explore
alveolar macrophage	3 studies	22% ± 7%	Explore
goblet cell	3 studies	26% ± 8%	Explore
transit amplifying cell	3 studies	40% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	30% ± 19%	Explore
lung	6 studies	22% ± 6%	Explore
eye	5 studies	22% ± 7%	Explore
peripheral blood	4 studies	30% ± 9%	Explore
bone marrow	3 studies	21% ± 3%	Explore
liver	3 studies	36% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2158.84	1445 / 1445	100%	34.83	183 / 183
lung	100%	2201.42	578 / 578	100%	30.06	1154 / 1155
breast	100%	2139.24	459 / 459	100%	33.35	1114 / 1118
uterus	100%	2300.60	170 / 170	100%	32.17	457 / 459
ovary	100%	1781.97	180 / 180	100%	16.51	428 / 430
prostate	100%	1849.26	245 / 245	99%	22.59	499 / 502
brain	99%	1345.40	2625 / 2642	100%	21.18	705 / 705
thymus	100%	2145.26	653 / 653	99%	24.03	600 / 605
bladder	100%	1981.29	21 / 21	98%	27.79	496 / 504
pancreas	99%	1109.15	326 / 328	99%	19.71	176 / 178
stomach	100%	1719.59	359 / 359	98%	27.80	279 / 286
intestine	100%	2364.58	966 / 966	97%	26.05	513 / 527
kidney	100%	1528.18	89 / 89	97%	18.08	876 / 901
adrenal gland	100%	1972.35	258 / 258	93%	12.18	215 / 230
liver	100%	1149.15	226 / 226	93%	14.42	377 / 406
skin	100%	2340.14	1809 / 1809	91%	22.61	431 / 472
blood vessel	100%	1845.15	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	35.15	29 / 29
spleen	100%	2472.32	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.03	45 / 45
ureter	0%	0	0 / 0	100%	12.60	1 / 1
adipose	100%	2054.12	1203 / 1204	0%	0	0 / 0
muscle	100%	1038.24	800 / 803	0%	0	0 / 0
heart	97%	998.64	834 / 861	0%	0	0 / 0
peripheral blood	86%	2226.93	797 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	61%	7.30	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008283	Biological process	cell population proliferation
GO_0060816	Biological process	random inactivation of X chromosome
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0140718	Biological process	facultative heterochromatin formation
GO_0048709	Biological process	oligodendrocyte differentiation
GO_0045596	Biological process	negative regulation of cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005677	Cellular component	chromatin silencing complex
GO_0016586	Cellular component	RSC-type complex
GO_0001739	Cellular component	sex chromatin
GO_0035098	Cellular component	ESC/E(Z) complex
GO_0016604	Cellular component	nuclear body
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0008047	Molecular function	enzyme activator activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0001222	Molecular function	transcription corepressor binding
GO_0042054	Molecular function	histone methyltransferase activity
GO_0106222	Molecular function	lncRNA binding
GO_0046872	Molecular function	metal ion binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SUZ12
Protein name	Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) SUZ12 polycomb repressive complex 2 subunit
Synonyms	JJAZ1 KIAA0160 CHET9
Description	FUNCTION: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene . The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems . Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A . .
Accessions	ENST00000322652.10 Q15022 ENST00000580398.1 J3QQW9

SUZ12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review