SMARCA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	32% ± 15%	Explore
fibroblast	24 studies	27% ± 10%	Explore
natural killer cell	23 studies	24% ± 7%	Explore
T cell	20 studies	25% ± 10%	Explore
CD8-positive, alpha-beta T cell	20 studies	22% ± 5%	Explore
astrocyte	19 studies	47% ± 21%	Explore
CD4-positive, alpha-beta T cell	16 studies	25% ± 7%	Explore
ciliated cell	15 studies	27% ± 8%	Explore
macrophage	15 studies	32% ± 17%	Explore
glutamatergic neuron	13 studies	50% ± 25%	Explore
oligodendrocyte precursor cell	13 studies	36% ± 15%	Explore
endothelial cell of lymphatic vessel	12 studies	27% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	28% ± 9%	Explore
B cell	12 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	28% ± 8%	Explore
microglial cell	12 studies	43% ± 12%	Explore
regulatory T cell	12 studies	21% ± 4%	Explore
gamma-delta T cell	12 studies	23% ± 8%	Explore
oligodendrocyte	12 studies	30% ± 11%	Explore
GABAergic neuron	11 studies	53% ± 26%	Explore
basal cell	10 studies	31% ± 14%	Explore
epithelial cell	10 studies	32% ± 15%	Explore
mucosal invariant T cell	10 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 8%	Explore
mature NK T cell	9 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	25% ± 9%	Explore
capillary endothelial cell	9 studies	23% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 5%	Explore
pericyte	8 studies	22% ± 5%	Explore
naive B cell	8 studies	22% ± 6%	Explore
adipocyte	8 studies	40% ± 13%	Explore
dendritic cell	8 studies	33% ± 12%	Explore
endothelial cell of artery	8 studies	23% ± 4%	Explore
mast cell	8 studies	28% ± 8%	Explore
plasmacytoid dendritic cell	8 studies	19% ± 4%	Explore
interneuron	7 studies	51% ± 30%	Explore
myeloid cell	7 studies	23% ± 6%	Explore
smooth muscle cell	7 studies	23% ± 7%	Explore
respiratory goblet cell	6 studies	28% ± 10%	Explore
non-classical monocyte	6 studies	24% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	25% ± 11%	Explore
connective tissue cell	6 studies	23% ± 7%	Explore
memory B cell	6 studies	19% ± 6%	Explore
club cell	6 studies	23% ± 4%	Explore
retinal cone cell	6 studies	23% ± 9%	Explore
T follicular helper cell	6 studies	22% ± 6%	Explore
endothelial cell of vascular tree	6 studies	30% ± 20%	Explore
innate lymphoid cell	6 studies	28% ± 11%	Explore
type I pneumocyte	6 studies	24% ± 5%	Explore
type II pneumocyte	6 studies	21% ± 4%	Explore
leukocyte	6 studies	36% ± 17%	Explore
myofibroblast cell	6 studies	25% ± 6%	Explore
hematopoietic precursor cell	5 studies	39% ± 15%	Explore
neuron	5 studies	40% ± 15%	Explore
monocyte	5 studies	29% ± 6%	Explore
vein endothelial cell	5 studies	28% ± 18%	Explore
lymphocyte	5 studies	36% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	26% ± 9%	Explore
secretory cell	4 studies	26% ± 4%	Explore
classical monocyte	4 studies	26% ± 12%	Explore
conventional dendritic cell	4 studies	41% ± 14%	Explore
progenitor cell	4 studies	20% ± 3%	Explore
granule cell	4 studies	36% ± 10%	Explore
amacrine cell	4 studies	33% ± 14%	Explore
retinal bipolar neuron	4 studies	25% ± 5%	Explore
retinal pigment epithelial cell	4 studies	39% ± 20%	Explore
cardiac muscle cell	4 studies	28% ± 2%	Explore
mesothelial cell	4 studies	32% ± 14%	Explore
Mueller cell	4 studies	21% ± 5%	Explore
retinal rod cell	4 studies	26% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 7%	Explore
hematopoietic stem cell	4 studies	33% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	38% ± 18%	Explore
enteroendocrine cell	4 studies	23% ± 7%	Explore
ionocyte	3 studies	31% ± 6%	Explore
pancreatic A cell	3 studies	47% ± 25%	Explore
type B pancreatic cell	3 studies	40% ± 22%	Explore
exhausted T cell	3 studies	23% ± 7%	Explore
GABAergic interneuron	3 studies	54% ± 15%	Explore
retinal ganglion cell	3 studies	29% ± 1%	Explore
serous secreting cell	3 studies	21% ± 4%	Explore
mononuclear phagocyte	3 studies	21% ± 2%	Explore
ON-bipolar cell	3 studies	29% ± 15%	Explore
glycinergic amacrine cell	3 studies	38% ± 15%	Explore
retina horizontal cell	3 studies	29% ± 15%	Explore
rod bipolar cell	3 studies	34% ± 9%	Explore
erythroblast	3 studies	27% ± 13%	Explore
CD4-positive helper T cell	3 studies	25% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 6%	Explore
hepatocyte	3 studies	44% ± 16%	Explore
ependymal cell	3 studies	43% ± 20%	Explore
adventitial cell	3 studies	22% ± 3%	Explore
alveolar macrophage	3 studies	30% ± 7%	Explore
chondrocyte	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 9%	Explore
goblet cell	3 studies	37% ± 20%	Explore
transit amplifying cell	3 studies	40% ± 27%	Explore
T-helper 17 cell	3 studies	21% ± 3%	Explore
renal alpha-intercalated cell	3 studies	21% ± 5%	Explore
renal principal cell	3 studies	37% ± 6%	Explore
mural cell	3 studies	43% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	42% ± 21%	Explore
lung	10 studies	23% ± 5%	Explore
eye	7 studies	28% ± 14%	Explore
peripheral blood	6 studies	26% ± 12%	Explore
liver	6 studies	18% ± 2%	Explore
kidney	5 studies	19% ± 4%	Explore
heart	4 studies	24% ± 4%	Explore
intestine	4 studies	19% ± 4%	Explore
pancreas	3 studies	37% ± 19%	Explore
bone marrow	3 studies	25% ± 10%	Explore
uterus	3 studies	25% ± 6%	Explore
breast	3 studies	19% ± 0%	Explore
adipose	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	10516.42	459 / 459	100%	33.46	1113 / 1118
prostate	100%	6814.87	245 / 245	99%	28.20	499 / 502
brain	100%	9415.34	2641 / 2642	99%	26.23	701 / 705
thymus	100%	10303.78	653 / 653	99%	26.93	600 / 605
pancreas	99%	3816.81	325 / 328	99%	18.73	176 / 178
intestine	100%	7312.88	966 / 966	97%	15.27	510 / 527
esophagus	100%	6462.91	1445 / 1445	96%	16.17	176 / 183
stomach	100%	4899.13	359 / 359	96%	14.59	275 / 286
kidney	100%	5528.93	89 / 89	96%	18.55	866 / 901
bladder	100%	7984.57	21 / 21	96%	15.17	484 / 504
uterus	100%	8577.51	170 / 170	96%	17.85	440 / 459
lung	100%	8628.92	578 / 578	95%	18.11	1102 / 1155
adrenal gland	100%	8611.08	258 / 258	95%	20.42	218 / 230
skin	100%	10281.37	1809 / 1809	93%	15.17	440 / 472
liver	98%	3354.40	222 / 226	82%	8.95	333 / 406
ovary	100%	15969.06	180 / 180	79%	9.29	340 / 430
adipose	100%	9233.87	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10671.23	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.81	29 / 29
spleen	100%	8103.38	241 / 241	0%	0	0 / 0
muscle	100%	6172.25	801 / 803	0%	0	0 / 0
heart	98%	5116.94	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	16.69	78 / 80
tonsil	0%	0	0 / 0	96%	29.61	43 / 45
peripheral blood	90%	6035.79	837 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0030071	Biological process	regulation of mitotic metaphase/anaphase transition
GO_0045582	Biological process	positive regulation of T cell differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0070316	Biological process	regulation of G0 to G1 transition
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_2000819	Biological process	regulation of nucleotide-excision repair
GO_0045596	Biological process	negative regulation of cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0007399	Biological process	nervous system development
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0007286	Biological process	spermatid development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0030308	Biological process	negative regulation of cell growth
GO_0140288	Cellular component	GBAF complex
GO_0071565	Cellular component	nBAF complex
GO_0071564	Cellular component	npBAF complex
GO_0016514	Cellular component	SWI/SNF complex
GO_0005654	Cellular component	nucleoplasm
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_0035060	Cellular component	brahma complex
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0000785	Cellular component	chromatin
GO_0140092	Cellular component	bBAF complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0004386	Molecular function	helicase activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0016787	Molecular function	hydrolase activity
GO_0005524	Molecular function	ATP binding
GO_0140658	Molecular function	ATP-dependent chromatin remodeler activity
GO_0008094	Molecular function	ATP-dependent activity, acting on DNA
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SMARCA2
Protein name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (cDNA FLJ61143, highly similar to Probable global transcription activator SNF2L2) Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2) SMARCA2 protein
Synonyms	BAF190B SNF2L2 SNF2A BRM
Description	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically . Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .
Accessions	ENST00000636903.1 ENST00000357248.8 [P51531-2] ENST00000635226.1 A0A1B0GTC9 ENST00000417599.6 A0A0U1RRF5 ENST00000704353.1 ENST00000637134.2 ENST00000423555.6 A0A994J6Z7 A0A0U1RRG6 ENST00000450198.6 A0A0U1RRN2 ENST00000302401.8 ENST00000439732.6 ENST00000634343.1 ENST00000452193.5 ENST00000704351.1 F6XE55 ENST00000635133.1 A0A0U1RQX3 ENST00000634338.1 A0A0U1RQU0 ENST00000382185.6 B1ALG2 ENST00000634989.1 ENST00000382194.6 [P51531-2] ENST00000635530.1 A0A0U1RRJ8 ENST00000634931.1 F6VDE0 ENST00000324954.10 F6T8Q0 ENST00000704350.1 ENST00000634772.1 B1ALF6 A0A1B0GU54 ENST00000634760.1 ENST00000416751.2 ENST00000634781.1 A0A0U1RR45 ENST00000382186.6 P51531 A0A0U1RR83 ENST00000635392.1 ENST00000635388.1 A0A0U1RQW7 A0A0U1RQP3 ENST00000704355.1 A0A0A0MT03 A0A994HRU5 ENST00000634287.1 ENST00000637806.1 ENST00000639760.2 ENST00000349721.8 [P51531-1] ENST00000636916.1 ENST00000634688.1 A0A994J4K2 ENST00000637383.1 A0A994J4C9 ENST00000635590.1 A0A0U1RRF8 B4DNT1 ENST00000636559.1 ENST00000634706.1 ENST00000634435.1 A0A1W2PS06 ENST00000704352.1 A0A994J4Z7 A0A994J7D9 F6RS74 ENST00000382183.6 ENST00000382203.5 [P51531-1] ENST00000635185.1 A0A0U1RR09 A0A1B0GWA8 A0A0U1RQE1 ENST00000635688.1 A0A1B0GUV6 F6UH26 A0A0A0MSS5 ENST00000704354.1 Q56A76 A0A0U1RQZ9 A0A0U1RR26 ENST00000635659.1 ENST00000637103.1 A0A0U1RRJ4 ENST00000636367.1 ENST00000457226.2 A0A0U1RQS1 A0A994J501 A0A0U1RRD6 B1ALG1

SMARCA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review