PRDM2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	36% ± 15%	Explore
endothelial cell	20 studies	28% ± 15%	Explore
naive B cell	18 studies	31% ± 13%	Explore
memory B cell	18 studies	33% ± 11%	Explore
fibroblast	17 studies	23% ± 8%	Explore
natural killer cell	14 studies	24% ± 7%	Explore
CD8-positive, alpha-beta T cell	12 studies	21% ± 6%	Explore
macrophage	12 studies	28% ± 12%	Explore
glutamatergic neuron	11 studies	48% ± 25%	Explore
microglial cell	11 studies	31% ± 11%	Explore
regulatory T cell	11 studies	24% ± 5%	Explore
astrocyte	11 studies	30% ± 14%	Explore
oligodendrocyte	11 studies	35% ± 11%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 13%	Explore
T cell	9 studies	29% ± 10%	Explore
endothelial cell of lymphatic vessel	8 studies	27% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	8 studies	24% ± 7%	Explore
adipocyte	8 studies	24% ± 6%	Explore
gamma-delta T cell	8 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	27% ± 8%	Explore
interneuron	7 studies	44% ± 20%	Explore
epithelial cell	7 studies	38% ± 24%	Explore
ciliated cell	7 studies	29% ± 14%	Explore
basal cell	7 studies	29% ± 17%	Explore
GABAergic neuron	7 studies	48% ± 20%	Explore
type I pneumocyte	6 studies	22% ± 5%	Explore
leukocyte	6 studies	24% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	24% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	26% ± 8%	Explore
neuron	6 studies	33% ± 12%	Explore
myeloid cell	6 studies	25% ± 4%	Explore
dendritic cell	6 studies	28% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	23% ± 4%	Explore
smooth muscle cell	6 studies	19% ± 3%	Explore
plasma cell	5 studies	30% ± 10%	Explore
retina horizontal cell	5 studies	25% ± 8%	Explore
mucosal invariant T cell	5 studies	20% ± 3%	Explore
lymphocyte	5 studies	35% ± 11%	Explore
pericyte	5 studies	22% ± 7%	Explore
monocyte	5 studies	26% ± 7%	Explore
club cell	5 studies	22% ± 7%	Explore
classical monocyte	4 studies	29% ± 11%	Explore
non-classical monocyte	4 studies	29% ± 11%	Explore
mature NK T cell	4 studies	25% ± 2%	Explore
granule cell	4 studies	24% ± 7%	Explore
precursor B cell	4 studies	31% ± 5%	Explore
immature B cell	4 studies	29% ± 14%	Explore
cardiac muscle cell	4 studies	22% ± 1%	Explore
mast cell	4 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 2%	Explore
abnormal cell	4 studies	23% ± 7%	Explore
type II pneumocyte	4 studies	19% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
conventional dendritic cell	3 studies	29% ± 16%	Explore
plasmablast	3 studies	37% ± 20%	Explore
GABAergic interneuron	3 studies	31% ± 6%	Explore
glial cell	3 studies	21% ± 3%	Explore
squamous epithelial cell	3 studies	36% ± 20%	Explore
pro-B cell	3 studies	30% ± 4%	Explore
retinal cone cell	3 studies	19% ± 1%	Explore
mononuclear phagocyte	3 studies	21% ± 6%	Explore
glycinergic amacrine cell	3 studies	20% ± 2%	Explore
connective tissue cell	3 studies	17% ± 2%	Explore
adventitial cell	3 studies	17% ± 3%	Explore
myofibroblast cell	3 studies	27% ± 5%	Explore
alveolar macrophage	3 studies	30% ± 9%	Explore
T follicular helper cell	3 studies	19% ± 4%	Explore
goblet cell	3 studies	38% ± 30%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	37% ± 20%	Explore
peripheral blood	7 studies	29% ± 14%	Explore
lung	6 studies	23% ± 5%	Explore
heart	4 studies	20% ± 2%	Explore
adipose	4 studies	26% ± 6%	Explore
eye	3 studies	29% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5052.04	1445 / 1445	100%	18.16	183 / 183
thymus	100%	5833.05	653 / 653	100%	21.40	605 / 605
breast	100%	4934.21	459 / 459	100%	21.37	1116 / 1118
bladder	100%	6040.19	21 / 21	100%	14.47	503 / 504
prostate	100%	5463.18	245 / 245	100%	17.56	501 / 502
ovary	100%	7599.88	180 / 180	100%	16.19	429 / 430
brain	100%	5003.34	2635 / 2642	100%	17.17	705 / 705
intestine	100%	5092.54	966 / 966	100%	12.25	525 / 527
uterus	100%	5870.02	170 / 170	100%	15.23	457 / 459
lung	100%	4423.96	577 / 578	100%	16.32	1150 / 1155
stomach	100%	3395.16	359 / 359	99%	13.04	283 / 286
skin	100%	5350.21	1809 / 1809	99%	15.61	466 / 472
pancreas	98%	1868.77	323 / 328	99%	13.58	176 / 178
kidney	100%	2645.09	89 / 89	95%	9.52	854 / 901
adrenal gland	100%	3323.49	258 / 258	93%	7.50	214 / 230
liver	94%	1234.72	213 / 226	56%	3.20	227 / 406
adipose	100%	4565.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4683.23	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.09	29 / 29
muscle	100%	4542.68	803 / 803	0%	0	0 / 0
spleen	100%	4362.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.33	45 / 45
ureter	0%	0	0 / 0	100%	5.41	1 / 1
heart	99%	2782.42	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	8.01	73 / 80
peripheral blood	91%	3816.10	843 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006338	Biological process	chromatin remodeling
GO_0008340	Biological process	determination of adult lifespan
GO_0032259	Biological process	methylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005634	Cellular component	nucleus
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0008270	Molecular function	zinc ion binding
GO_0140949	Molecular function	histone H3K9 trimethyltransferase activity

IV. Literature review

[source]

Gene name	PRDM2
Protein name	PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) PR/SET domain 2
Synonyms	RIZ KMT8
Description	FUNCTION: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. .
Accessions	D6RED5 ENST00000503842.5 ENST00000487453.1 ENST00000407521.7 ENST00000484063.6 H0Y9J3 ENST00000311066.10 [Q13029-1] ENST00000376048.9 [Q13029-4] ENST00000235372.11 [Q13029-1] ENST00000505823.5 Q13029 ENST00000413440.5 [Q13029-5] ENST00000343137.8 [Q13029-5] D6RAA0 ENST00000491134.5 S4R3F7 D6RJM6

PRDM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review