Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 29% ± 13% | |
| astrocyte | 10 studies | 29% ± 12% | |
| adipocyte | 9 studies | 28% ± 9% | |
| oligodendrocyte | 9 studies | 31% ± 10% | |
| glutamatergic neuron | 8 studies | 43% ± 23% | |
| microglial cell | 8 studies | 26% ± 9% | |
| oligodendrocyte precursor cell | 8 studies | 28% ± 14% | |
| macrophage | 8 studies | 30% ± 14% | |
| fibroblast | 7 studies | 24% ± 9% | |
| neuron | 6 studies | 33% ± 17% | |
| epithelial cell | 6 studies | 31% ± 15% | |
| GABAergic neuron | 6 studies | 45% ± 17% | |
| smooth muscle cell | 6 studies | 23% ± 6% | |
| interneuron | 5 studies | 41% ± 22% | |
| cardiac muscle cell | 5 studies | 23% ± 5% | |
| dendritic cell | 5 studies | 20% ± 6% | |
| ciliated cell | 5 studies | 27% ± 7% | |
| mast cell | 5 studies | 19% ± 6% | |
| endothelial cell of lymphatic vessel | 5 studies | 25% ± 6% | |
| club cell | 5 studies | 26% ± 7% | |
| type I pneumocyte | 5 studies | 30% ± 9% | |
| type II pneumocyte | 5 studies | 27% ± 7% | |
| myeloid cell | 4 studies | 26% ± 8% | |
| pericyte | 4 studies | 29% ± 13% | |
| basal cell | 4 studies | 34% ± 14% | |
| granule cell | 3 studies | 24% ± 7% | |
| plasma cell | 3 studies | 33% ± 4% | |
| hepatocyte | 3 studies | 43% ± 27% | |
| T cell | 3 studies | 18% ± 2% | |
| alveolar macrophage | 3 studies | 29% ± 6% | |
| monocyte | 3 studies | 24% ± 3% | |
| lymphocyte | 3 studies | 27% ± 5% | |
| muscle cell | 3 studies | 31% ± 19% | |
| transit amplifying cell | 3 studies | 33% ± 21% | |
| mucus secreting cell | 3 studies | 25% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3257.76 | 21 / 21 | 100% | 23.45 | 504 / 504 |
| esophagus | 100% | 3350.86 | 1445 / 1445 | 100% | 31.25 | 183 / 183 |
| ovary | 100% | 3243.10 | 180 / 180 | 100% | 28.73 | 430 / 430 |
| prostate | 100% | 3476.33 | 245 / 245 | 100% | 16.86 | 502 / 502 |
| stomach | 100% | 2644.51 | 359 / 359 | 100% | 22.03 | 286 / 286 |
| uterus | 100% | 3961.59 | 170 / 170 | 100% | 26.36 | 459 / 459 |
| lung | 100% | 3453.39 | 578 / 578 | 100% | 27.50 | 1154 / 1155 |
| breast | 100% | 2996.26 | 459 / 459 | 100% | 27.79 | 1116 / 1118 |
| skin | 100% | 4162.11 | 1809 / 1809 | 100% | 26.82 | 471 / 472 |
| thymus | 100% | 3007.60 | 652 / 653 | 100% | 19.78 | 604 / 605 |
| intestine | 100% | 3429.04 | 966 / 966 | 100% | 20.96 | 525 / 527 |
| brain | 99% | 2510.19 | 2625 / 2642 | 100% | 19.72 | 705 / 705 |
| pancreas | 100% | 1933.22 | 327 / 328 | 99% | 15.48 | 176 / 178 |
| adrenal gland | 100% | 5385.48 | 258 / 258 | 98% | 17.64 | 225 / 230 |
| kidney | 100% | 2126.45 | 89 / 89 | 98% | 11.45 | 881 / 901 |
| liver | 100% | 1789.26 | 226 / 226 | 94% | 9.92 | 382 / 406 |
| adipose | 100% | 2967.23 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3160.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 20.00 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.67 | 29 / 29 |
| muscle | 100% | 4719.38 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2642.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 24.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.33 | 1 / 1 |
| heart | 99% | 2238.83 | 849 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 1889.47 | 845 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010906 | Biological process | regulation of glucose metabolic process |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0001678 | Biological process | intracellular glucose homeostasis |
| GO_0042594 | Biological process | response to starvation |
| GO_0061621 | Biological process | canonical glycolysis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FOXK2 |
| Protein name | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) Forkhead box K2 |
| Synonyms | ILF ILF1 |
| Description | FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context . Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription . Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence . Binds to NFAT-like motifs (purine-rich) in the IL2 promoter . Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus . Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements . . |
| Accessions | ENST00000526383.2 ENST00000335255.10 [Q01167-1] Q01167 I3L4U8 E9PM37 E9PPI7 ENST00000531030.5 ENST00000575578.1 ENST00000473637.6 [Q01167-2] |