Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 32 studies | 37% ± 19% | |
| endothelial cell of artery | 14 studies | 42% ± 16% | |
| capillary endothelial cell | 14 studies | 36% ± 14% | |
| vein endothelial cell | 11 studies | 32% ± 13% | |
| endothelial cell of lymphatic vessel | 10 studies | 32% ± 11% | |
| endothelial cell of vascular tree | 6 studies | 28% ± 19% | |
| pericyte | 3 studies | 39% ± 26% |
Insufficient scRNA-seq data for expression of SOX18 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 99% | 2653.72 | 649 / 653 | 96% | 29.80 | 583 / 605 |
| esophagus | 94% | 1495.17 | 1362 / 1445 | 99% | 37.41 | 181 / 183 |
| breast | 100% | 3644.64 | 458 / 459 | 91% | 17.36 | 1017 / 1118 |
| adrenal gland | 96% | 1141.44 | 247 / 258 | 94% | 28.80 | 216 / 230 |
| bladder | 100% | 1694.57 | 21 / 21 | 87% | 13.62 | 439 / 504 |
| stomach | 90% | 1057.58 | 324 / 359 | 91% | 30.16 | 261 / 286 |
| lung | 99% | 2573.80 | 571 / 578 | 81% | 14.76 | 936 / 1155 |
| prostate | 98% | 1565.82 | 239 / 245 | 82% | 10.93 | 412 / 502 |
| uterus | 100% | 2578.11 | 170 / 170 | 79% | 14.91 | 363 / 459 |
| intestine | 96% | 1325.11 | 926 / 966 | 83% | 16.63 | 438 / 527 |
| kidney | 97% | 1522.08 | 86 / 89 | 78% | 29.05 | 701 / 901 |
| skin | 65% | 690.61 | 1169 / 1809 | 88% | 13.37 | 414 / 472 |
| ovary | 51% | 556.26 | 92 / 180 | 100% | 72.50 | 429 / 430 |
| brain | 64% | 459.76 | 1699 / 2642 | 74% | 10.30 | 522 / 705 |
| pancreas | 45% | 262.68 | 147 / 328 | 92% | 16.44 | 164 / 178 |
| liver | 21% | 116.34 | 47 / 226 | 90% | 14.40 | 366 / 406 |
| adipose | 100% | 4050.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.55 | 29 / 29 |
| spleen | 100% | 1876.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.65 | 1 / 1 |
| heart | 99% | 2532.71 | 853 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 19.83 | 39 / 45 |
| muscle | 84% | 631.16 | 671 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 77% | 1155.69 | 1029 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 57% | 5.03 | 46 / 80 |
| peripheral blood | 2% | 17.60 | 22 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0060836 | Biological process | lymphatic endothelial cell differentiation |
| GO_0001947 | Biological process | heart looping |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0001946 | Biological process | lymphangiogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0048866 | Biological process | stem cell fate specification |
| GO_0060956 | Biological process | endocardial cell differentiation |
| GO_0060214 | Biological process | endocardium formation |
| GO_0043534 | Biological process | blood vessel endothelial cell migration |
| GO_0022405 | Biological process | hair cycle process |
| GO_0001944 | Biological process | vasculature development |
| GO_0072091 | Biological process | regulation of stem cell proliferation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0035050 | Biological process | embryonic heart tube development |
| GO_0001942 | Biological process | hair follicle development |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0048469 | Biological process | cell maturation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| Gene name | SOX18 |
| Protein name | Transcription factor SOX-18 |
| Synonyms | |
| Description | FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. . |
| Accessions | P35713 ENST00000340356.9 |
