I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 28% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 28% ± 3% |
Insufficient scRNA-seq data for expression of KLF8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 3003.62 | 458 / 459 | 91% | 4.38 | 1013 / 1118 |
| kidney | 97% | 1419.71 | 86 / 89 | 92% | 6.77 | 829 / 901 |
| thymus | 100% | 1443.02 | 651 / 653 | 87% | 3.80 | 524 / 605 |
| ovary | 100% | 1905.44 | 180 / 180 | 84% | 2.44 | 361 / 430 |
| lung | 98% | 1295.81 | 569 / 578 | 79% | 3.35 | 914 / 1155 |
| esophagus | 100% | 2806.13 | 1445 / 1445 | 69% | 4.13 | 127 / 183 |
| uterus | 100% | 2608.36 | 170 / 170 | 69% | 3.23 | 318 / 459 |
| bladder | 100% | 1410.67 | 21 / 21 | 64% | 3.18 | 321 / 504 |
| prostate | 99% | 1165.16 | 242 / 245 | 57% | 0.96 | 286 / 502 |
| intestine | 91% | 1144.66 | 882 / 966 | 24% | 0.51 | 128 / 527 |
| skin | 77% | 3732.43 | 1386 / 1809 | 28% | 0.59 | 131 / 472 |
| adipose | 100% | 2837.30 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.63 | 1 / 1 |
| blood vessel | 100% | 2377.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 97% | 1095.47 | 234 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 11% | 62.49 | 36 / 328 | 70% | 1.96 | 124 / 178 |
| stomach | 50% | 524.59 | 181 / 359 | 29% | 0.62 | 84 / 286 |
| adrenal gland | 53% | 319.39 | 138 / 258 | 24% | 0.39 | 55 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 2.76 | 31 / 45 |
| heart | 69% | 551.13 | 590 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 2.27 | 16 / 29 |
| brain | 28% | 170.99 | 744 / 2642 | 26% | 0.45 | 186 / 705 |
| muscle | 43% | 276.13 | 348 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 224.94 | 187 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.28 | 14 / 80 |
| liver | 0% | 1.90 | 1 / 226 | 5% | 0.12 | 19 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0016235 | Cellular component | aggresome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | KLF8 |
| Protein name | KLF transcription factor 8 (KLF8 protein) (Kruppel-like factor 8, isoform CRA_b) Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741) |
| Synonyms | BKLF3 ZNF741 hCG_17979 |
| Description | FUNCTION: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). . |
| Accessions | ENST00000358094.7 ENST00000374928.7 [O95600-3] Q05BZ3 ENST00000468660.6 [O95600-1] O95600 ENST00000640927.1 [O95600-4] |
