ARID5B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	51% ± 15%	Explore
B cell	38 studies	38% ± 11%	Explore
pericyte	37 studies	48% ± 18%	Explore
endothelial cell	34 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	30% ± 11%	Explore
smooth muscle cell	29 studies	51% ± 17%	Explore
regulatory T cell	29 studies	48% ± 13%	Explore
T cell	27 studies	27% ± 8%	Explore
endothelial cell of lymphatic vessel	25 studies	46% ± 17%	Explore
natural killer cell	23 studies	22% ± 6%	Explore
basal cell	21 studies	37% ± 15%	Explore
CD8-positive, alpha-beta T cell	21 studies	25% ± 7%	Explore
memory B cell	20 studies	37% ± 12%	Explore
naive B cell	19 studies	32% ± 8%	Explore
connective tissue cell	17 studies	42% ± 15%	Explore
epithelial cell	17 studies	38% ± 23%	Explore
macrophage	16 studies	29% ± 12%	Explore
myofibroblast cell	15 studies	44% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	33% ± 10%	Explore
astrocyte	14 studies	29% ± 12%	Explore
mature NK T cell	13 studies	25% ± 8%	Explore
oligodendrocyte	13 studies	34% ± 12%	Explore
mesothelial cell	13 studies	42% ± 14%	Explore
endothelial cell of vascular tree	13 studies	42% ± 20%	Explore
gamma-delta T cell	13 studies	26% ± 12%	Explore
plasma cell	12 studies	36% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 8%	Explore
adipocyte	11 studies	51% ± 20%	Explore
type I pneumocyte	10 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	32% ± 12%	Explore
glutamatergic neuron	10 studies	50% ± 25%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 10%	Explore
ciliated cell	10 studies	27% ± 15%	Explore
type II pneumocyte	9 studies	34% ± 12%	Explore
GABAergic neuron	9 studies	44% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	20% ± 5%	Explore
epithelial cell of proximal tubule	9 studies	25% ± 13%	Explore
microglial cell	9 studies	24% ± 7%	Explore
myeloid cell	9 studies	32% ± 7%	Explore
secretory cell	9 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	25% ± 3%	Explore
leukocyte	8 studies	22% ± 6%	Explore
endothelial cell of artery	8 studies	28% ± 11%	Explore
kidney loop of Henle epithelial cell	7 studies	34% ± 6%	Explore
club cell	7 studies	41% ± 15%	Explore
T follicular helper cell	7 studies	41% ± 11%	Explore
progenitor cell	6 studies	25% ± 7%	Explore
interneuron	6 studies	47% ± 22%	Explore
abnormal cell	6 studies	34% ± 7%	Explore
retina horizontal cell	6 studies	30% ± 8%	Explore
vein endothelial cell	6 studies	41% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	33% ± 15%	Explore
CD4-positive helper T cell	5 studies	33% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	34% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	22% ± 6%	Explore
non-classical monocyte	5 studies	22% ± 4%	Explore
plasmablast	5 studies	28% ± 9%	Explore
capillary endothelial cell	5 studies	26% ± 9%	Explore
amacrine cell	5 studies	41% ± 13%	Explore
adventitial cell	5 studies	49% ± 12%	Explore
cardiac muscle cell	5 studies	31% ± 6%	Explore
dendritic cell	5 studies	22% ± 5%	Explore
lymphocyte	5 studies	48% ± 18%	Explore
respiratory goblet cell	5 studies	37% ± 15%	Explore
mast cell	5 studies	33% ± 18%	Explore
monocyte	5 studies	31% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 13%	Explore
duct epithelial cell	4 studies	21% ± 7%	Explore
squamous epithelial cell	4 studies	40% ± 18%	Explore
pancreatic A cell	4 studies	31% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
conventional dendritic cell	4 studies	26% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	33% ± 7%	Explore
neuron	4 studies	46% ± 13%	Explore
intestinal crypt stem cell	4 studies	29% ± 12%	Explore
IgA plasma cell	4 studies	34% ± 19%	Explore
immature B cell	4 studies	33% ± 6%	Explore
precursor B cell	4 studies	34% ± 10%	Explore
retinal bipolar neuron	4 studies	31% ± 6%	Explore
mononuclear phagocyte	4 studies	21% ± 6%	Explore
mucosal invariant T cell	4 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	38% ± 16%	Explore
myoepithelial cell	4 studies	60% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	44% ± 9%	Explore
muscle cell	4 studies	66% ± 6%	Explore
type B pancreatic cell	3 studies	39% ± 3%	Explore
exhausted T cell	3 studies	33% ± 10%	Explore
glomerular endothelial cell	3 studies	17% ± 1%	Explore
podocyte	3 studies	31% ± 10%	Explore
GABAergic interneuron	3 studies	36% ± 5%	Explore
extravillous trophoblast	3 studies	19% ± 1%	Explore
placental villous trophoblast	3 studies	42% ± 4%	Explore
pro-B cell	3 studies	34% ± 10%	Explore
retinal pigment epithelial cell	3 studies	38% ± 17%	Explore
Mueller cell	3 studies	24% ± 2%	Explore
ON-bipolar cell	3 studies	26% ± 4%	Explore
rod bipolar cell	3 studies	52% ± 4%	Explore
IgG plasma cell	3 studies	30% ± 12%	Explore
alveolar macrophage	3 studies	31% ± 10%	Explore
Schwann cell	3 studies	44% ± 23%	Explore
transit amplifying cell	3 studies	42% ± 28%	Explore
keratinocyte	3 studies	39% ± 16%	Explore
T-helper 1 cell	3 studies	29% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 5%	Explore
double negative thymocyte	3 studies	25% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	23% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	43% ± 13%	Explore
parietal epithelial cell	3 studies	32% ± 6%	Explore
mural cell	3 studies	35% ± 19%	Explore
mucus secreting cell	3 studies	34% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	38% ± 19%	Explore
lung	16 studies	28% ± 7%	Explore
peripheral blood	13 studies	23% ± 6%	Explore
kidney	10 studies	25% ± 5%	Explore
intestine	9 studies	21% ± 8%	Explore
eye	5 studies	32% ± 19%	Explore
heart	5 studies	27% ± 5%	Explore
uterus	5 studies	40% ± 14%	Explore
breast	5 studies	40% ± 17%	Explore
lymph node	4 studies	27% ± 8%	Explore
prostate	4 studies	41% ± 3%	Explore
adipose	4 studies	35% ± 8%	Explore
skin	4 studies	33% ± 16%	Explore
pancreas	3 studies	33% ± 1%	Explore
placenta	3 studies	36% ± 13%	Explore
liver	3 studies	29% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	5480.29	244 / 245	100%	51.11	502 / 502
ovary	99%	5546.49	179 / 180	99%	30.46	426 / 430
lung	100%	5916.66	576 / 578	98%	28.03	1137 / 1155
esophagus	100%	4790.91	1439 / 1445	98%	31.13	180 / 183
uterus	100%	10165.32	170 / 170	97%	26.76	443 / 459
breast	100%	10011.66	459 / 459	97%	32.35	1079 / 1118
intestine	99%	5551.03	953 / 966	97%	21.23	510 / 527
skin	100%	7222.38	1808 / 1809	95%	34.06	450 / 472
bladder	100%	6404.10	21 / 21	95%	22.57	479 / 504
stomach	94%	3062.10	336 / 359	97%	26.20	276 / 286
kidney	99%	3771.82	88 / 89	91%	31.77	816 / 901
thymus	90%	2925.08	587 / 653	72%	13.37	438 / 605
brain	48%	1027.41	1270 / 2642	99%	24.54	695 / 705
adrenal gland	76%	1788.89	195 / 258	40%	5.90	93 / 230
pancreas	9%	153.46	29 / 328	96%	22.27	170 / 178
adipose	100%	11303.25	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10774.93	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	96.18	80 / 80
ureter	0%	0	0 / 0	100%	25.34	1 / 1
spleen	100%	3224.14	240 / 241	0%	0	0 / 0
muscle	99%	17634.68	794 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	30.58	44 / 45
lymph node	0%	0	0 / 0	93%	23.82	27 / 29
heart	85%	3299.19	729 / 861	0%	0	0 / 0
peripheral blood	47%	1180.41	436 / 929	0%	0	0 / 0
liver	15%	290.08	34 / 226	30%	3.72	120 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009791	Biological process	post-embryonic development
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045444	Biological process	fat cell differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0010761	Biological process	fibroblast migration
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0035264	Biological process	multicellular organism growth
GO_0001822	Biological process	kidney development
GO_0001889	Biological process	liver development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0060021	Biological process	roof of mouth development
GO_0060613	Biological process	fat pad development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0048468	Biological process	cell development
GO_0030325	Biological process	adrenal gland development
GO_0048644	Biological process	muscle organ morphogenesis
GO_0060612	Biological process	adipose tissue development
GO_0008584	Biological process	male gonad development
GO_0060325	Biological process	face morphogenesis
GO_0008585	Biological process	female gonad development
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0048705	Biological process	skeletal system morphogenesis
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARID5B
Protein name	AT-rich interactive domain 5B (MRF1-like) AT-rich interaction domain 5B AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)
Synonyms	MRF2 DESRT
Description	FUNCTION: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. .
Accessions	A0A7P0TAD2 A0A0B6XJY6 A0A2R8Y5F2 ENST00000309334.5 [Q14865-2] ENST00000644638.1 ENST00000279873.12 [Q14865-1] Q14865 ENST00000681100.1

ARID5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review