I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 29% ± 1% | |
| glutamatergic neuron | 3 studies | 36% ± 5% | |
| transit amplifying cell | 3 studies | 26% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 29% ± 1% | |
| glutamatergic neuron | 3 studies | 36% ± 5% | |
| transit amplifying cell | 3 studies | 26% ± 13% |
Insufficient scRNA-seq data for expression of CDC7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 791.16 | 2590 / 2642 | 99% | 15.60 | 697 / 705 |
| lung | 99% | 690.87 | 575 / 578 | 96% | 12.36 | 1104 / 1155 |
| uterus | 93% | 350.11 | 158 / 170 | 98% | 28.07 | 451 / 459 |
| skin | 94% | 529.85 | 1705 / 1809 | 95% | 16.52 | 448 / 472 |
| breast | 92% | 282.59 | 421 / 459 | 95% | 13.67 | 1063 / 1118 |
| ovary | 92% | 390.39 | 166 / 180 | 94% | 11.53 | 406 / 430 |
| bladder | 90% | 351.62 | 19 / 21 | 95% | 13.36 | 478 / 504 |
| intestine | 91% | 394.08 | 880 / 966 | 92% | 9.49 | 486 / 527 |
| esophagus | 85% | 377.82 | 1226 / 1445 | 96% | 13.40 | 176 / 183 |
| stomach | 67% | 196.92 | 240 / 359 | 91% | 9.98 | 260 / 286 |
| kidney | 91% | 355.56 | 81 / 89 | 65% | 3.86 | 582 / 901 |
| thymus | 92% | 307.16 | 604 / 653 | 61% | 4.47 | 370 / 605 |
| adrenal gland | 98% | 416.58 | 254 / 258 | 47% | 3.70 | 109 / 230 |
| pancreas | 43% | 123.93 | 140 / 328 | 81% | 5.74 | 144 / 178 |
| prostate | 92% | 323.24 | 226 / 245 | 29% | 1.45 | 147 / 502 |
| spleen | 100% | 1669.88 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 24.92 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.07 | 1 / 1 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 15.46 | 28 / 29 |
| adipose | 93% | 305.99 | 1116 / 1204 | 0% | 0 | 0 / 0 |
| liver | 43% | 104.47 | 97 / 226 | 45% | 3.38 | 181 / 406 |
| peripheral blood | 55% | 567.43 | 509 / 929 | 0% | 0 | 0 / 0 |
| heart | 48% | 111.15 | 416 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 40% | 100.55 | 536 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 23% | 1.22 | 18 / 80 |
| muscle | 10% | 23.57 | 78 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
| GO_0007165 | Biological process | signal transduction |
| GO_0051301 | Biological process | cell division |
| GO_0000727 | Biological process | double-strand break repair via break-induced replication |
| GO_0010571 | Biological process | positive regulation of nuclear cell cycle DNA replication |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0044770 | Biological process | cell cycle phase transition |
| GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0045171 | Cellular component | intercellular bridge |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016301 | Molecular function | kinase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CDC7 |
| Protein name | Cell division cycle 7 Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) Cell division cycle 7-like protein 1 |
| Synonyms | CDC7L1 |
| Description | FUNCTION: Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. . |
| Accessions | O00311 ENST00000428239.5 [O00311-1] Q6JSD6 ENST00000426137.1 B1AMW7 ENST00000234626.11 [O00311-1] |
