VRK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_2000659Biological processregulation of interleukin-1-mediated signaling pathway
GO_0007165Biological processsignal transduction
GO_0034599Biological processcellular response to oxidative stress
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0046777Biological processprotein autophosphorylation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005635Cellular componentnuclear envelope
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVRK2
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
VRK serine/threonine kinase 2
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Synonyms
DescriptionFUNCTION: Serine/threonine kinase that regulates several signal transduction pathways . Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes . Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription . Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 . Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins . Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 . Blocks the phosphorylation of ERK in response to ERBB2 and HRAS . Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant . .; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. .

AccessionsENST00000435505.6 [Q86Y07-1]
E9PBU1
ENST00000417641.6 [Q86Y07-5]
Q86Y07
ENST00000412104.6 [Q86Y07-4]
ENST00000440705.6 [Q86Y07-3]
Q05CR6
ENST00000428021.1
E7ERS5
ENST00000432057.2
ENST00000648897.1 [Q86Y07-2]
ENST00000340157.9 [Q86Y07-1]