RASA2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	30 studies	30% ± 12%	Explore
endothelial cell	21 studies	35% ± 14%	Explore
CD8-positive, alpha-beta T cell	20 studies	26% ± 9%	Explore
T cell	19 studies	26% ± 12%	Explore
CD4-positive, alpha-beta T cell	17 studies	27% ± 11%	Explore
regulatory T cell	15 studies	27% ± 8%	Explore
mast cell	14 studies	32% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	33% ± 11%	Explore
gamma-delta T cell	13 studies	24% ± 5%	Explore
glutamatergic neuron	12 studies	48% ± 27%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	35% ± 15%	Explore
mature NK T cell	12 studies	26% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	22% ± 5%	Explore
astrocyte	11 studies	32% ± 15%	Explore
macrophage	11 studies	41% ± 18%	Explore
microglial cell	11 studies	32% ± 12%	Explore
mucosal invariant T cell	11 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 7%	Explore
GABAergic neuron	10 studies	43% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 9%	Explore
oligodendrocyte precursor cell	10 studies	34% ± 14%	Explore
oligodendrocyte	10 studies	28% ± 10%	Explore
B cell	9 studies	28% ± 11%	Explore
pericyte	9 studies	29% ± 12%	Explore
naive B cell	9 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 12%	Explore
epithelial cell	8 studies	31% ± 18%	Explore
fibroblast	8 studies	25% ± 7%	Explore
innate lymphoid cell	8 studies	35% ± 15%	Explore
myeloid cell	7 studies	26% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 4%	Explore
interneuron	6 studies	51% ± 21%	Explore
adipocyte	5 studies	20% ± 4%	Explore
dendritic cell	5 studies	34% ± 5%	Explore
endothelial cell of lymphatic vessel	5 studies	34% ± 9%	Explore
monocyte	5 studies	36% ± 7%	Explore
club cell	5 studies	28% ± 11%	Explore
smooth muscle cell	5 studies	23% ± 3%	Explore
type I pneumocyte	5 studies	34% ± 9%	Explore
type II pneumocyte	5 studies	23% ± 5%	Explore
classical monocyte	4 studies	19% ± 2%	Explore
neuron	4 studies	42% ± 7%	Explore
granule cell	4 studies	35% ± 4%	Explore
plasma cell	4 studies	39% ± 5%	Explore
ciliated cell	4 studies	26% ± 7%	Explore
lymphocyte	4 studies	56% ± 22%	Explore
retinal rod cell	4 studies	38% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 15%	Explore
neutrophil	3 studies	23% ± 10%	Explore
squamous epithelial cell	3 studies	38% ± 19%	Explore
exhausted T cell	3 studies	25% ± 6%	Explore
plasmablast	3 studies	27% ± 10%	Explore
GABAergic interneuron	3 studies	37% ± 9%	Explore
Mueller cell	3 studies	25% ± 10%	Explore
amacrine cell	3 studies	20% ± 3%	Explore
ependymal cell	3 studies	28% ± 12%	Explore
alveolar macrophage	3 studies	37% ± 10%	Explore
respiratory goblet cell	3 studies	33% ± 15%	Explore
T follicular helper cell	3 studies	22% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 8%	Explore
basal cell	3 studies	39% ± 23%	Explore
goblet cell	3 studies	38% ± 30%	Explore
leukocyte	3 studies	57% ± 25%	Explore
transit amplifying cell	3 studies	40% ± 31%	Explore
mural cell	3 studies	46% ± 24%	Explore
mucus secreting cell	3 studies	27% ± 5%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	16 studies	38% ± 21%	Explore
peripheral blood	8 studies	19% ± 2%	Explore
lung	6 studies	25% ± 8%	Explore
eye	5 studies	32% ± 12%	Explore
adipose	4 studies	23% ± 5%	Explore
heart	3 studies	18% ± 4%	Explore
kidney	3 studies	18% ± 2%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1640.78	1445 / 1445	100%	19.73	183 / 183
lung	100%	2774.36	578 / 578	100%	15.12	1154 / 1155
breast	100%	2176.86	459 / 459	99%	15.93	1108 / 1118
ovary	100%	2580.15	180 / 180	99%	9.59	424 / 430
bladder	100%	1955.71	21 / 21	98%	12.57	492 / 504
uterus	100%	2620.94	170 / 170	97%	14.66	446 / 459
brain	98%	1532.12	2601 / 2642	98%	9.15	694 / 705
thymus	100%	1878.75	652 / 653	97%	11.66	587 / 605
prostate	100%	1965.25	245 / 245	97%	9.35	486 / 502
stomach	100%	1209.42	359 / 359	97%	12.57	276 / 286
pancreas	98%	845.91	322 / 328	98%	14.79	174 / 178
intestine	100%	1978.73	966 / 966	96%	12.26	504 / 527
kidney	100%	1406.52	89 / 89	94%	10.04	845 / 901
skin	100%	2244.57	1808 / 1809	91%	12.95	429 / 472
adrenal gland	100%	1165.95	258 / 258	87%	5.91	200 / 230
liver	97%	651.26	219 / 226	65%	3.91	262 / 406
spleen	100%	3333.42	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.72	1 / 1
blood vessel	100%	1825.03	1334 / 1335	0%	0	0 / 0
adipose	100%	2071.91	1203 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	12.61	44 / 45
peripheral blood	96%	1973.59	895 / 929	0%	0	0 / 0
heart	94%	779.41	806 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	16.60	27 / 29
muscle	91%	619.72	731 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	48%	2.88	38 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0