RHOH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0030217Biological processT cell differentiation
GO_0007015Biological processactin filament organization
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0045576Biological processmast cell activation
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005095Molecular functionGTPase inhibitor activity
GO_0005525Molecular functionGTP binding
GO_0031267Molecular functionsmall GTPase binding
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0019210Molecular functionkinase inhibitor activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRHOH
Protein nameARHH protein (Ras homolog gene family, member H, isoform CRA_a) (cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA)
Rho-related GTP-binding protein RhoH
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
SynonymsARHH
TTF
hCG_37394
DescriptionFUNCTION: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. .

AccessionsQ6ICP4
D6R8Z1
ENST00000508513.5
ENST00000381799.10
ENST00000511121.6
ENST00000614836.2
ENST00000515702.2
ENST00000507851.6
D6RG23
D6RA52
ENST00000503978.2
ENST00000503754.6
ENST00000515503.6
ENST00000505618.6
ENST00000511967.6
ENST00000503941.6
ENST00000507851.5
ENST00000503941.5
Q15669
ENST00000508513.6
ENST00000513894.6
ENST00000515718.6