RASA3 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	25% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 6%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	11 studies	23% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
regulatory T cell	9 studies	25% ± 6%	Explore
mature NK T cell	8 studies	22% ± 4%	Explore
mucosal invariant T cell	8 studies	22% ± 5%	Explore
adipocyte	8 studies	22% ± 4%	Explore
microglial cell	7 studies	36% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
platelet	6 studies	19% ± 2%	Explore
T cell	6 studies	24% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
astrocyte	5 studies	28% ± 10%	Explore
fibroblast	5 studies	22% ± 5%	Explore
macrophage	5 studies	24% ± 10%	Explore
gamma-delta T cell	5 studies	23% ± 4%	Explore
non-classical monocyte	4 studies	21% ± 4%	Explore
monocyte	4 studies	22% ± 1%	Explore
oligodendrocyte	4 studies	26% ± 8%	Explore
interneuron	3 studies	30% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 7%	Explore
retina horizontal cell	3 studies	18% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	29% ± 5%	Explore
myeloid cell	3 studies	19% ± 3%	Explore
megakaryocyte	3 studies	35% ± 3%	Explore
pericyte	3 studies	27% ± 5%	Explore
lymphocyte	3 studies	52% ± 8%	Explore
mast cell	3 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 6%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	19% ± 2%	Explore
brain	4 studies	32% ± 6%	Explore
adipose	4 studies	20% ± 5%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	3625.13	1807 / 1809	100%	63.82	470 / 472
thymus	100%	3286.99	652 / 653	100%	38.42	602 / 605
brain	99%	2425.07	2622 / 2642	100%	60.29	704 / 705
breast	100%	4970.95	459 / 459	96%	24.03	1076 / 1118
intestine	100%	3121.79	964 / 966	88%	19.36	465 / 527
lung	100%	4011.90	577 / 578	86%	15.55	989 / 1155
pancreas	91%	1195.47	300 / 328	93%	39.83	166 / 178
prostate	99%	2479.87	243 / 245	85%	10.94	429 / 502
stomach	89%	1551.69	320 / 359	91%	19.56	261 / 286
uterus	100%	3462.67	170 / 170	78%	15.89	356 / 459
esophagus	87%	2605.68	1253 / 1445	83%	17.26	151 / 183
bladder	100%	3895.19	21 / 21	68%	13.67	345 / 504
kidney	80%	1483.63	71 / 89	88%	23.99	796 / 901
ovary	93%	1479.37	167 / 180	68%	10.03	294 / 430
adrenal gland	57%	525.37	147 / 258	63%	10.91	146 / 230
adipose	100%	6398.08	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	32.63	29 / 29
spleen	100%	4630.95	241 / 241	0%	0	0 / 0
blood vessel	100%	3589.68	1333 / 1335	0%	0	0 / 0
peripheral blood	98%	3744.63	908 / 929	0%	0	0 / 0
heart	94%	1544.07	807 / 861	0%	0	0 / 0
muscle	93%	1649.01	748 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	93%	26.23	74 / 80
tonsil	0%	0	0 / 0	73%	11.01	33 / 45
liver	31%	281.62	69 / 226	36%	5.77	147 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1