IL25 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL25 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL25 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0009624Biological processresponse to nematode
GO_0009620Biological processresponse to fungus
GO_0030222Biological processeosinophil differentiation
GO_0008150Biological processbiological_process
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0030380Molecular functioninterleukin-17E receptor binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL25
Protein nameInterleukin-25 (IL-25) (Interleukin-17E) (IL-17E)
SynonymsIL17E
UNQ3120/PRO10272
DescriptionFUNCTION: Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production . Promotes and augments T-helper type 2 responses locally or systemically . Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 . Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways . Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 . .

AccessionsENST00000397242.3 [Q9H293-2]
ENST00000329715.2 [Q9H293-1]
Q9H293