I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type B pancreatic cell | 3 studies | 30% ± 8% | |
| fibroblast | 3 studies | 51% ± 22% | |
| epithelial cell | 3 studies | 22% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type B pancreatic cell | 3 studies | 30% ± 8% | |
| fibroblast | 3 studies | 51% ± 22% | |
| epithelial cell | 3 studies | 22% ± 6% |
Insufficient scRNA-seq data for expression of EDN3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 92% | 547.76 | 301 / 328 | 78% | 23.23 | 139 / 178 |
| brain | 76% | 295.11 | 2014 / 2642 | 86% | 10.92 | 603 / 705 |
| thymus | 98% | 2380.90 | 638 / 653 | 60% | 30.05 | 366 / 605 |
| intestine | 67% | 1196.63 | 649 / 966 | 63% | 7.98 | 333 / 527 |
| prostate | 84% | 693.87 | 207 / 245 | 31% | 1.62 | 156 / 502 |
| esophagus | 80% | 1079.44 | 1158 / 1445 | 30% | 3.29 | 55 / 183 |
| spleen | 88% | 503.37 | 212 / 241 | 0% | 0 | 0 / 0 |
| stomach | 18% | 64.31 | 65 / 359 | 58% | 5.84 | 165 / 286 |
| breast | 34% | 244.73 | 158 / 459 | 19% | 2.45 | 207 / 1118 |
| ovary | 26% | 120.82 | 46 / 180 | 24% | 4.85 | 104 / 430 |
| skin | 28% | 89.07 | 499 / 1809 | 18% | 84.05 | 87 / 472 |
| adrenal gland | 28% | 96.85 | 72 / 258 | 10% | 2.65 | 22 / 230 |
| uterus | 15% | 343.01 | 26 / 170 | 17% | 11.04 | 78 / 459 |
| eye | 0% | 0 | 0 / 0 | 29% | 2.71 | 23 / 80 |
| bladder | 0% | 0 | 0 / 21 | 19% | 1.91 | 94 / 504 |
| lung | 7% | 19.81 | 41 / 578 | 11% | 2.02 | 123 / 1155 |
| kidney | 2% | 12.11 | 2 / 89 | 3% | 0.38 | 24 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.64 | 2 / 45 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.10 | 7 / 406 |
| adipose | 1% | 2.95 | 17 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.99 | 11 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.29 | 1 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.14 | 1 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.10 | 1 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
| GO_0003100 | Biological process | regulation of systemic arterial blood pressure by endothelin |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0048070 | Biological process | regulation of developmental pigmentation |
| GO_0019229 | Biological process | regulation of vasoconstriction |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0007165 | Biological process | signal transduction |
| GO_0030593 | Biological process | neutrophil chemotaxis |
| GO_0010961 | Biological process | intracellular magnesium ion homeostasis |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0030318 | Biological process | melanocyte differentiation |
| GO_0030072 | Biological process | peptide hormone secretion |
| GO_0008015 | Biological process | blood circulation |
| GO_0014824 | Biological process | artery smooth muscle contraction |
| GO_0048675 | Biological process | axon extension |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0042310 | Biological process | vasoconstriction |
| GO_0014826 | Biological process | vein smooth muscle contraction |
| GO_0046887 | Biological process | positive regulation of hormone secretion |
| GO_0060585 | Biological process | positive regulation of prostaglandin-endoperoxide synthase activity |
| GO_0002690 | Biological process | positive regulation of leukocyte chemotaxis |
| GO_0010460 | Biological process | positive regulation of heart rate |
| GO_0007411 | Biological process | axon guidance |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031708 | Molecular function | endothelin B receptor binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| Gene name | EDN3 |
| Protein name | Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) Endothelin-3 (Preproendothelin-3) |
| Synonyms | |
| Description | FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides. FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides. . FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides. . FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides. . FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides. . |
| Accessions | P14138 ENST00000337938.7 [P14138-1] ENST00000311585.11 [P14138-3] A0A2R8Y214 ENST00000395654.3 [P14138-2] ENST00000672969.1 Q6LDQ8 ENST00000644821.1 ENST00000371025.7 ENST00000371028.6 [P14138-1] A0A5F9ZHX0 Q4FAT2 |
