TENM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_1903385Biological processregulation of homophilic cell adhesion
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0048666Biological processneuron development
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0010976Biological processpositive regulation of neuron projection development
GO_0048593Biological processcamera-type eye morphogenesis
GO_0030424Cellular componentaxon
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0016020Cellular componentmembrane
GO_0050839Molecular functioncell adhesion molecule binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0042803Molecular functionprotein homodimerization activity

IV. Literature review

[source]
Gene nameTENM3
Protein nameTeneurin transmembrane protein 3
Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3)
SynonymsODZ3
KIAA1455
TNM3
DescriptionFUNCTION: Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. .

AccessionsENST00000512480.5
ENST00000511685.6
H0YAF0
D6RGC5
Q9P273
ENST00000510504.1