PRMT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048588Biological processdevelopmental cell growth
GO_0007165Biological processsignal transduction
GO_0006338Biological processchromatin remodeling
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0006479Biological processprotein methylation
GO_0019919Biological processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0042054Molecular functionhistone methyltransferase activity
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0035242Molecular functionprotein-arginine omega-N asymmetric methyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0033142Molecular functionnuclear progesterone receptor binding
GO_0005515Molecular functionprotein binding
GO_0140592Molecular functionhistone H3R8 methyltransferase activity

IV. Literature review

[source]
Gene namePRMT2
Protein nameProtein arginine methyltransferase 2 isoform 2
Protein arginine methyltransferase 2 isoform 3
PRMT2 protein
Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2)
Protein arginine methyltransferase 2
Protein arginine methyltransferase 2 isoform 1
SynonymsHRMT1L1
HMT1
DescriptionFUNCTION: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. .

AccessionsA0A0S2Z3W8
ENST00000355680.8 [P55345-1]
ENST00000458387.6 [P55345-5]
H7C2H9
A0A0S2Z3Q3
ENST00000334494.8 [P55345-2]
ENST00000451211.6 [P55345-4]
P55345
ENST00000397637.5 [P55345-1]
ENST00000397628.5
ENST00000455177.3
A0A0S2Z3N3
ENST00000291705.11 [P55345-6]
ENST00000397638.6 [P55345-1]
A8MXR3
Q49AF9
ENST00000440086.5 [P55345-3]