GRIA1 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	67% ± 21%	Explore
GABAergic neuron	11 studies	66% ± 27%	Explore
astrocyte	11 studies	43% ± 17%	Explore
oligodendrocyte precursor cell	9 studies	30% ± 12%	Explore
interneuron	7 studies	68% ± 27%	Explore
neuron	5 studies	34% ± 18%	Explore
Mueller cell	5 studies	46% ± 20%	Explore
endothelial cell	4 studies	45% ± 19%	Explore
GABAergic interneuron	3 studies	70% ± 25%	Explore
retinal bipolar neuron	3 studies	45% ± 24%	Explore
GABAergic amacrine cell	3 studies	45% ± 16%	Explore
rod bipolar cell	3 studies	47% ± 21%	Explore
fibroblast	3 studies	28% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	46% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	7119.87	2505 / 2642	99%	73.51	697 / 705
lung	90%	2479.49	520 / 578	12%	0.40	144 / 1155
blood vessel	49%	1219.15	651 / 1335	0%	0	0 / 0
adrenal gland	1%	11.54	3 / 258	30%	2.62	68 / 230
skin	24%	671.08	432 / 1809	6%	0.89	26 / 472
adipose	14%	128.13	172 / 1204	0%	0	0 / 0
breast	3%	30.42	16 / 459	8%	2.42	94 / 1118
stomach	9%	90.57	32 / 359	2%	0.05	7 / 286
eye	0%	0	0 / 0	9%	0.69	7 / 80
uterus	0%	0	0 / 170	5%	0.28	25 / 459
kidney	0%	0	0 / 89	5%	0.22	47 / 901
esophagus	4%	32.84	62 / 1445	1%	0.01	1 / 183
intestine	4%	31.44	40 / 966	1%	0.01	3 / 527
pancreas	0%	0	0 / 328	3%	0.27	5 / 178
bladder	0%	0	0 / 21	3%	0.13	13 / 504
thymus	1%	5.03	5 / 653	1%	0.05	4 / 605
peripheral blood	1%	15.32	12 / 929	0%	0	0 / 0
ovary	1%	3.27	1 / 180	0%	0.01	2 / 430
heart	1%	4.48	6 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0.00	1 / 406
muscle	0%	0.67	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031623	Biological process	receptor internalization
GO_0021510	Biological process	spinal cord development
GO_0035235	Biological process	ionotropic glutamate receptor signaling pathway
GO_0010226	Biological process	response to lithium ion
GO_0060992	Biological process	response to fungicide
GO_0071242	Biological process	cellular response to ammonium ion
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0060292	Biological process	long-term synaptic depression
GO_0060291	Biological process	long-term synaptic potentiation
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_0042220	Biological process	response to cocaine
GO_0019228	Biological process	neuronal action potential
GO_0071375	Biological process	cellular response to peptide hormone stimulus
GO_0032355	Biological process	response to estradiol
GO_0019722	Biological process	calcium-mediated signaling
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0071359	Biological process	cellular response to dsRNA
GO_0046685	Biological process	response to arsenic-containing substance
GO_0007268	Biological process	chemical synaptic transmission
GO_0045838	Biological process	positive regulation of membrane potential
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0007416	Biological process	synapse assembly
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0099566	Biological process	regulation of postsynaptic cytosolic calcium ion concentration
GO_1990416	Biological process	cellular response to brain-derived neurotrophic factor stimulus
GO_0051602	Biological process	response to electrical stimulus
GO_0007616	Biological process	long-term memory
GO_0001919	Biological process	regulation of receptor recycling
GO_0071418	Biological process	cellular response to amine stimulus
GO_0021987	Biological process	cerebral cortex development
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0098793	Cellular component	presynapse
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0044309	Cellular component	neuron spine
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0043025	Cellular component	neuronal cell body
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0032591	Cellular component	dendritic spine membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0060076	Cellular component	excitatory synapse
GO_0099092	Cellular component	postsynaptic density, intracellular component
GO_0097060	Cellular component	synaptic membrane
GO_0031901	Cellular component	early endosome membrane
GO_0055038	Cellular component	recycling endosome membrane
GO_0030425	Cellular component	dendrite
GO_0044308	Cellular component	axonal spine
GO_0005886	Cellular component	plasma membrane
GO_0055037	Cellular component	recycling endosome
GO_0043198	Cellular component	dendritic shaft
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0032281	Cellular component	AMPA glutamate receptor complex
GO_0099544	Cellular component	perisynaptic space
GO_0014069	Cellular component	postsynaptic density
GO_0012507	Cellular component	ER to Golgi transport vesicle membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0043197	Cellular component	dendritic spine
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0032809	Cellular component	neuronal cell body membrane
GO_0005911	Cellular component	cell-cell junction
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0099583	Molecular function	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0042802	Molecular function	identical protein binding
GO_0097110	Molecular function	scaffold protein binding
GO_0008179	Molecular function	adenylate cyclase binding
GO_0022849	Molecular function	glutamate-gated calcium ion channel activity
GO_0051018	Molecular function	protein kinase A binding
GO_0008066	Molecular function	glutamate receptor activity
GO_0031681	Molecular function	G-protein beta-subunit binding
GO_0019865	Molecular function	immunoglobulin binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0035254	Molecular function	glutamate receptor binding
GO_0030165	Molecular function	PDZ domain binding
GO_0031698	Molecular function	beta-2 adrenergic receptor binding
GO_0004971	Molecular function	AMPA glutamate receptor activity
GO_0099507	Molecular function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005515	Molecular function	protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0031267	Molecular function	small GTPase binding
GO_0031489	Molecular function	myosin V binding

IV. Literature review

[source]

Gene name	GRIA1
Protein name	Glutamate receptor Glutamate ionotropic receptor AMPA type subunit 1 Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) Glutamate receptor 1 variant
Synonyms	GLUR1 GLUH1
Description	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .
Accessions	ENST00000520353.6 ENST00000285900.10 [P42261-1] ENST00000521843.6 [P42261-4] A0A9L9PXX0 ENST00000706734.1 A0A9L9PXA5 P42261 ENST00000706733.1 ENST00000706767.1 A0A9L9PYA4 A0A9L9PXG3 ENST00000448073.8 [P42261-6] ENST00000518783.1 [P42261-5] C5IJI6 ENST00000340592.10 [P42261-2] ENST00000518142.5 [P42261-3]

GRIA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review