MET report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_1905098Biological processnegative regulation of guanyl-nucleotide exchange factor activity
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0031016Biological processpancreas development
GO_0061436Biological processestablishment of skin barrier
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0050918Biological processpositive chemotaxis
GO_0060079Biological processexcitatory postsynaptic potential
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_0001889Biological processliver development
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0033674Biological processpositive regulation of kinase activity
GO_0030182Biological processneuron differentiation
GO_2001028Biological processpositive regulation of endothelial cell chemotaxis
GO_0070495Biological processnegative regulation of thrombin-activated receptor signaling pathway
GO_0006909Biological processphagocytosis
GO_1901299Biological processnegative regulation of hydrogen peroxide-mediated programmed cell death
GO_0010507Biological processnegative regulation of autophagy
GO_0048012Biological processhepatocyte growth factor receptor signaling pathway
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0001886Biological processendothelial cell morphogenesis
GO_0007399Biological processnervous system development
GO_0016477Biological processcell migration
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007166Biological processcell surface receptor signaling pathway
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0098794Cellular componentpostsynapse
GO_0009925Cellular componentbasal plasma membrane
GO_0009986Cellular componentcell surface
GO_0017154Molecular functionsemaphorin receptor activity
GO_0140677Molecular functionmolecular function activator activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005008Molecular functionhepatocyte growth factor receptor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMET
Protein nameSoluble MET variant 7
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
MET proto-oncogene, receptor tyrosine kinase
Soluble MET variant 14
Soluble MET variant 6
Soluble MET variant 8
Soluble MET variant 15
MET proto-oncogene, receptor tyrosine kinase (Met proto-oncogene variant I)
Soluble MET variant 5
MET protein
Proto-oncogenic met protein
Soluble MET variant 13
Soluble MET variant 9
Soluble MET variant 3
Soluble MET variant 1
Soluble MET variant 12
Soluble MET variant 11
Soluble MET variant 10
Soluble MET variant 2
Synonyms
DescriptionFUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. .

AccessionsENST00000454623.1
B5A942
B5A943
E6Y365
B5A937
B5A940
B5A936
B5A941
ENST00000436117.3 [P08581-3]
C9JKM5
B5A929
B5A931
ENST00000397752.8 [P08581-1]
P08581
B5A939
ENST00000422097.2
B5A938
ENST00000456159.1
H7C130
B5A935
Q14825
Q9UEJ3
B5A930
A0PJF7
ENST00000318493.11 [P08581-2]
B5A934
B5A933