PKN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0003014Biological processrenal system process
GO_0001783Biological processB cell apoptotic process
GO_0010631Biological processepithelial cell migration
GO_0002634Biological processregulation of germinal center formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0001782Biological processB cell homeostasis
GO_0002637Biological processregulation of immunoglobulin production
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0048536Biological processspleen development
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0006972Biological processhyperosmotic response
GO_0035556Biological processintracellular signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000145Biological processregulation of cell motility
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0030496Cellular componentmidbody
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0032154Cellular componentcleavage furrow
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0035402Molecular functionhistone H3T11 kinase activity
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene namePKN1
Protein nameSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Protein kinase N1
SynonymsPAK1
PRKCL1
PKN
PRK1
DescriptionFUNCTION: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. .

AccessionsK7EKY9
Q16512
ENST00000342216.8 [Q16512-2]
ENST00000242783.11 [Q16512-1]
K7EPK3
K7ES10
ENST00000586557.5
ENST00000586237.1
K7EN76
ENST00000591461.1
ENST00000585619.5
ENST00000592960.1
K7EL10
K7EM57
ENST00000590097.5