Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 32% ± 16% | |
| macrophage | 22 studies | 38% ± 21% | |
| oligodendrocyte precursor cell | 10 studies | 29% ± 15% | |
| oligodendrocyte | 10 studies | 38% ± 12% | |
| GABAergic neuron | 9 studies | 45% ± 19% | |
| fibroblast | 9 studies | 29% ± 11% | |
| myeloid cell | 8 studies | 30% ± 11% | |
| adipocyte | 8 studies | 27% ± 7% | |
| epithelial cell | 7 studies | 34% ± 15% | |
| retinal cone cell | 7 studies | 36% ± 13% | |
| astrocyte | 7 studies | 34% ± 16% | |
| glutamatergic neuron | 6 studies | 44% ± 22% | |
| interneuron | 6 studies | 49% ± 25% | |
| microglial cell | 6 studies | 27% ± 6% | |
| endothelial cell of lymphatic vessel | 6 studies | 29% ± 10% | |
| CD4-positive, alpha-beta T cell | 5 studies | 23% ± 2% | |
| cardiac muscle cell | 5 studies | 36% ± 11% | |
| T cell | 5 studies | 25% ± 8% | |
| type I pneumocyte | 5 studies | 30% ± 9% | |
| type II pneumocyte | 5 studies | 26% ± 8% | |
| basal cell | 5 studies | 32% ± 20% | |
| effector memory CD8-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
| dendritic cell | 4 studies | 21% ± 4% | |
| ciliated cell | 4 studies | 21% ± 4% | |
| lymphocyte | 4 studies | 29% ± 16% | |
| retina horizontal cell | 4 studies | 30% ± 13% | |
| retinal rod cell | 4 studies | 27% ± 8% | |
| hepatocyte | 4 studies | 66% ± 20% | |
| club cell | 4 studies | 26% ± 6% | |
| pericyte | 4 studies | 24% ± 4% | |
| endothelial cell of sinusoid | 3 studies | 29% ± 14% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 23% ± 6% | |
| GABAergic interneuron | 3 studies | 33% ± 4% | |
| retinal ganglion cell | 3 studies | 29% ± 13% | |
| CD8-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
| mononuclear phagocyte | 3 studies | 33% ± 10% | |
| vein endothelial cell | 3 studies | 38% ± 21% | |
| endothelial cell of vascular tree | 3 studies | 33% ± 13% | |
| myofibroblast cell | 3 studies | 21% ± 7% | |
| alveolar macrophage | 3 studies | 24% ± 7% | |
| monocyte | 3 studies | 27% ± 4% | |
| natural killer cell | 3 studies | 22% ± 4% | |
| regulatory T cell | 3 studies | 23% ± 7% | |
| goblet cell | 3 studies | 43% ± 25% | |
| neuron | 3 studies | 57% ± 24% | |
| smooth muscle cell | 3 studies | 21% ± 3% | |
| renal alpha-intercalated cell | 3 studies | 31% ± 10% | |
| mucus secreting cell | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3201.14 | 1445 / 1445 | 100% | 37.49 | 183 / 183 |
| prostate | 100% | 3498.86 | 245 / 245 | 100% | 54.63 | 501 / 502 |
| breast | 100% | 4754.91 | 459 / 459 | 100% | 121.91 | 1115 / 1118 |
| liver | 100% | 4019.63 | 226 / 226 | 99% | 54.56 | 403 / 406 |
| lung | 100% | 3086.80 | 576 / 578 | 100% | 33.55 | 1150 / 1155 |
| intestine | 100% | 3583.62 | 966 / 966 | 98% | 35.78 | 519 / 527 |
| pancreas | 99% | 1921.18 | 326 / 328 | 99% | 35.27 | 176 / 178 |
| stomach | 100% | 2704.64 | 359 / 359 | 98% | 38.09 | 281 / 286 |
| kidney | 100% | 3699.44 | 89 / 89 | 97% | 35.81 | 876 / 901 |
| bladder | 100% | 3426.00 | 21 / 21 | 97% | 29.78 | 487 / 504 |
| thymus | 100% | 2718.09 | 653 / 653 | 96% | 21.46 | 583 / 605 |
| brain | 100% | 2272.93 | 2629 / 2642 | 97% | 16.76 | 682 / 705 |
| uterus | 100% | 2497.87 | 170 / 170 | 96% | 26.33 | 439 / 459 |
| skin | 100% | 3532.52 | 1808 / 1809 | 93% | 25.23 | 439 / 472 |
| ovary | 100% | 2610.48 | 180 / 180 | 91% | 16.25 | 390 / 430 |
| adrenal gland | 100% | 2437.33 | 258 / 258 | 86% | 16.94 | 198 / 230 |
| adipose | 100% | 4420.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2545.96 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 9674.61 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2909.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 33.67 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 36.58 | 1 / 1 |
| heart | 98% | 3889.38 | 840 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 84% | 19.91 | 67 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 15.71 | 22 / 29 |
| peripheral blood | 54% | 898.64 | 502 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0007417 | Biological process | central nervous system development |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WWP1 |
| Protein name | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) HECT-type E3 ubiquitin transferase (EC 2.3.2.26) |
| Synonyms | |
| Description | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. . |
| Accessions | ENST00000265428.4 [Q9H0M0-1] ENST00000520798.5 Q9H0M0 H0YBS9 ENST00000520453.5 H0YBA4 ENST00000517970.6 [Q9H0M0-1] |