Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 16 studies | 25% ± 6% | |
| microglial cell | 7 studies | 22% ± 6% | |
| classical monocyte | 6 studies | 25% ± 9% | |
| alveolar macrophage | 5 studies | 24% ± 10% | |
| monocyte | 5 studies | 21% ± 3% | |
| myeloid cell | 5 studies | 34% ± 10% | |
| goblet cell | 5 studies | 32% ± 5% | |
| non-classical monocyte | 4 studies | 26% ± 8% | |
| conventional dendritic cell | 4 studies | 20% ± 7% | |
| epithelial cell | 4 studies | 34% ± 12% | |
| dendritic cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1522.62 | 245 / 245 | 100% | 20.12 | 502 / 502 |
| thymus | 100% | 1180.64 | 653 / 653 | 100% | 12.29 | 605 / 605 |
| lung | 100% | 2044.57 | 578 / 578 | 99% | 15.99 | 1149 / 1155 |
| breast | 100% | 1293.28 | 459 / 459 | 99% | 19.40 | 1112 / 1118 |
| ovary | 100% | 1518.95 | 180 / 180 | 99% | 11.27 | 427 / 430 |
| intestine | 100% | 2157.18 | 966 / 966 | 99% | 15.13 | 523 / 527 |
| pancreas | 100% | 2121.23 | 328 / 328 | 99% | 16.35 | 176 / 178 |
| stomach | 100% | 1519.56 | 359 / 359 | 99% | 13.60 | 282 / 286 |
| skin | 99% | 708.60 | 1797 / 1809 | 99% | 14.18 | 468 / 472 |
| kidney | 100% | 1627.51 | 89 / 89 | 98% | 16.64 | 886 / 901 |
| uterus | 100% | 992.19 | 170 / 170 | 96% | 11.20 | 442 / 459 |
| adrenal gland | 100% | 1135.29 | 257 / 258 | 96% | 8.18 | 221 / 230 |
| bladder | 100% | 1181.81 | 21 / 21 | 95% | 11.73 | 477 / 504 |
| brain | 96% | 1041.31 | 2534 / 2642 | 97% | 8.17 | 684 / 705 |
| liver | 100% | 955.30 | 226 / 226 | 91% | 11.03 | 371 / 406 |
| esophagus | 96% | 672.88 | 1382 / 1445 | 93% | 8.25 | 171 / 183 |
| adipose | 100% | 1173.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 13.51 | 29 / 29 |
| spleen | 100% | 1961.62 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.71 | 1 / 1 |
| blood vessel | 100% | 1063.86 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 1444.29 | 920 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 25.98 | 79 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 9.06 | 43 / 45 |
| heart | 86% | 399.70 | 742 / 861 | 0% | 0 | 0 / 0 |
| muscle | 10% | 30.61 | 80 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0097190 | Biological process | apoptotic signaling pathway |
| GO_1900027 | Biological process | regulation of ruffle assembly |
| GO_1904141 | Biological process | positive regulation of microglial cell migration |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0002931 | Biological process | response to ischemia |
| GO_0002028 | Biological process | regulation of sodium ion transport |
| GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0010524 | Biological process | positive regulation of calcium ion transport into cytosol |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0033198 | Biological process | response to ATP |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0007165 | Biological process | signal transduction |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0048678 | Biological process | response to axon injury |
| GO_0071294 | Biological process | cellular response to zinc ion |
| GO_0035590 | Biological process | purinergic nucleotide receptor signaling pathway |
| GO_0034405 | Biological process | response to fluid shear stress |
| GO_0055119 | Biological process | relaxation of cardiac muscle |
| GO_0042118 | Biological process | endothelial cell activation |
| GO_0071318 | Biological process | cellular response to ATP |
| GO_0050920 | Biological process | regulation of chemotaxis |
| GO_0019228 | Biological process | neuronal action potential |
| GO_2001028 | Biological process | positive regulation of endothelial cell chemotaxis |
| GO_0045429 | Biological process | positive regulation of nitric oxide biosynthetic process |
| GO_0050975 | Biological process | sensory perception of touch |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0051928 | Biological process | positive regulation of calcium ion transport |
| GO_0032308 | Biological process | positive regulation of prostaglandin secretion |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0048266 | Biological process | behavioral response to pain |
| GO_0001894 | Biological process | tissue homeostasis |
| GO_0055117 | Biological process | regulation of cardiac muscle contraction |
| GO_0010614 | Biological process | negative regulation of cardiac muscle hypertrophy |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0043195 | Cellular component | terminal bouton |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0044297 | Cellular component | cell body |
| GO_0030054 | Cellular component | cell junction |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0001614 | Molecular function | purinergic nucleotide receptor activity |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0099604 | Molecular function | ligand-gated calcium channel activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0004931 | Molecular function | extracellularly ATP-gated monoatomic cation channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | P2RX4 |
| Protein name | Purinergic receptor P2X4 Purinergic receptor P2X 4 ATP receptor (Purinergic receptor) P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) |
| Synonyms | hCG_27358 |
| Description | FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium . Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology . Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC . Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity). . |
| Accessions | K4KBD6 Q99571 F5GZQ9 F5H2S3 ENST00000543984.5 ENST00000543318.5 ENST00000538417.2 ENST00000359949.11 [Q99571-2] ENST00000542067.5 [Q99571-3] F5H1M6 H0YF70 ENST00000337233.9 [Q99571-1] ENST00000538701.5 B7Z4R5 |
