PRKAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0051170Biological processimport into nucleus
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0006110Biological processregulation of glycolytic process
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0031669Biological processcellular response to nutrient levels
GO_0006633Biological processfatty acid biosynthetic process
GO_0050790Biological processregulation of catalytic activity
GO_0006468Biological processprotein phosphorylation
GO_0016020Cellular componentmembrane
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043531Molecular functionADP binding
GO_0019887Molecular functionprotein kinase regulator activity
GO_0008603Molecular functioncAMP-dependent protein kinase regulator activity
GO_0016208Molecular functionAMP binding
GO_0019901Molecular functionprotein kinase binding
GO_0004672Molecular functionprotein kinase activity
GO_0004691Molecular functioncAMP-dependent protein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKAG1
Protein nameProtein kinase AMP-activated non-catalytic subunit gamma 1
5'-AMP-activated protein kinase subunit gamma-1
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)
Synonyms
DescriptionFUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation . AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators . Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin . Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits . ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit . ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive . .

AccessionsENST00000548950.5
F8VZX1
ENST00000552212.5 [P54619-2]
ENST00000551121.5
F8W046
F8VSL2
ENST00000548065.7 [P54619-1]
ENST00000547082.1
F8VPF5
ENST00000547306.5
ENST00000548857.5
ENST00000551696.5
ENST00000551770.5
ENST00000316299.9 [P54619-3]
ENST00000548605.5
F8VQQ1
F8VYY9
F8VSH3
H0YHF8
F8VRY2
ENST00000552463.5
ENST00000546531.5
ENST00000548362.5
H0YIC9
F8VVA3
F8VYZ8
ENST00000547125.1
P54619