Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 5 studies | 22% ± 6% | |
epithelial cell | 5 studies | 30% ± 13% | |
macrophage | 5 studies | 17% ± 2% | |
GABAergic neuron | 4 studies | 31% ± 14% | |
glutamatergic neuron | 4 studies | 36% ± 16% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 18% ± 2% | |
classical monocyte | 3 studies | 22% ± 4% | |
conventional dendritic cell | 3 studies | 30% ± 11% | |
non-classical monocyte | 3 studies | 26% ± 7% | |
fibroblast | 3 studies | 25% ± 5% | |
astrocyte | 3 studies | 23% ± 5% | |
dendritic cell | 3 studies | 34% ± 7% | |
natural killer cell | 3 studies | 19% ± 3% | |
basal cell | 3 studies | 25% ± 9% | |
interneuron | 3 studies | 26% ± 14% | |
neuron | 3 studies | 24% ± 6% | |
oligodendrocyte | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2864.75 | 459 / 459 | 100% | 59.71 | 1118 / 1118 |
intestine | 100% | 2780.71 | 966 / 966 | 100% | 40.45 | 527 / 527 |
ovary | 100% | 2026.61 | 180 / 180 | 100% | 41.91 | 430 / 430 |
prostate | 100% | 2635.16 | 245 / 245 | 100% | 51.87 | 502 / 502 |
skin | 100% | 3620.62 | 1809 / 1809 | 100% | 54.91 | 472 / 472 |
stomach | 100% | 2086.87 | 359 / 359 | 100% | 36.59 | 286 / 286 |
uterus | 100% | 2410.06 | 170 / 170 | 100% | 41.79 | 459 / 459 |
thymus | 100% | 2321.70 | 653 / 653 | 100% | 45.71 | 604 / 605 |
kidney | 100% | 2455.45 | 89 / 89 | 100% | 41.43 | 899 / 901 |
pancreas | 100% | 1582.77 | 327 / 328 | 100% | 36.02 | 178 / 178 |
lung | 100% | 2158.03 | 576 / 578 | 100% | 44.31 | 1155 / 1155 |
bladder | 100% | 2831.90 | 21 / 21 | 100% | 42.44 | 502 / 504 |
brain | 100% | 1955.64 | 2631 / 2642 | 100% | 50.50 | 705 / 705 |
liver | 100% | 1555.02 | 225 / 226 | 100% | 29.06 | 406 / 406 |
esophagus | 100% | 3012.43 | 1445 / 1445 | 99% | 29.93 | 182 / 183 |
adrenal gland | 100% | 4085.59 | 258 / 258 | 99% | 42.39 | 228 / 230 |
adipose | 100% | 3047.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2723.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 64.73 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 42.59 | 29 / 29 |
muscle | 100% | 4902.57 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2388.68 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 42.25 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 19.27 | 1 / 1 |
heart | 98% | 3205.17 | 847 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 2170.69 | 909 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007283 | Biological process | spermatogenesis |
GO_0051170 | Biological process | import into nucleus |
GO_0007165 | Biological process | signal transduction |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0006110 | Biological process | regulation of glycolytic process |
GO_0045860 | Biological process | positive regulation of protein kinase activity |
GO_0031669 | Biological process | cellular response to nutrient levels |
GO_0006633 | Biological process | fatty acid biosynthetic process |
GO_0050790 | Biological process | regulation of catalytic activity |
GO_0006468 | Biological process | protein phosphorylation |
GO_0016020 | Cellular component | membrane |
GO_0031588 | Cellular component | nucleotide-activated protein kinase complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0043531 | Molecular function | ADP binding |
GO_0019887 | Molecular function | protein kinase regulator activity |
GO_0008603 | Molecular function | cAMP-dependent protein kinase regulator activity |
GO_0016208 | Molecular function | AMP binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0004691 | Molecular function | cAMP-dependent protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PRKAG1 |
Protein name | Protein kinase AMP-activated non-catalytic subunit gamma 1 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) |
Synonyms | |
Description | FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation . AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators . Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin . Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits . ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit . ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive . . |
Accessions | ENST00000548950.5 F8VZX1 ENST00000552212.5 [P54619-2] ENST00000551121.5 F8W046 F8VSL2 ENST00000548065.7 [P54619-1] ENST00000547082.1 F8VPF5 ENST00000547306.5 ENST00000548857.5 ENST00000551696.5 ENST00000551770.5 ENST00000316299.9 [P54619-3] ENST00000548605.5 F8VQQ1 F8VYY9 F8VSH3 H0YHF8 F8VRY2 ENST00000552463.5 ENST00000546531.5 ENST00000548362.5 H0YIC9 F8VVA3 F8VYZ8 ENST00000547125.1 P54619 |