SRGAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003363Biological processlamellipodium assembly involved in ameboidal cell migration
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_1904861Biological processexcitatory synapse assembly
GO_0048812Biological processneuron projection morphogenesis
GO_0051014Biological processactin filament severing
GO_1904862Biological processinhibitory synapse assembly
GO_0060996Biological processdendritic spine development
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0046847Biological processfilopodium assembly
GO_0021816Biological processextension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO_0030336Biological processnegative regulation of cell migration
GO_2001223Biological processnegative regulation of neuron migration
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0044327Cellular componentdendritic spine head
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSRGAP2
Protein nameSLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)
SLIT-ROBO Rho GTPase activating protein 2
SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2 protein)
SLIT-ROBO Rho GTPase-activating protein 2
SynonymsFNBP2
KIAA0456
RP11-421E17.2-001
SRGAP2A
RP11-421E17.2-002
ARHGAP34
RP11-421E17.2-005
DescriptionFUNCTION: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex . Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons . SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation . Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia . .

AccessionsENST00000604010.1
ENST00000605476.5
ENST00000419187.6
ENST00000573034.8
A0A075B7E6
A0A075B7B5
ENST00000604925.5
Q5VZB4
ENST00000624873.3
A0A1S5UZH8
O75044
ENST00000605610.5
Q5VZB5
E9PDX4
ENST00000572793.2
A0A075B743
A0A075B7E9
B7ZM87
Q5VZB3