Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 22 studies | 33% ± 16% | |
macrophage | 19 studies | 36% ± 20% | |
microglial cell | 15 studies | 73% ± 19% | |
myeloid cell | 10 studies | 35% ± 11% | |
glutamatergic neuron | 9 studies | 34% ± 22% | |
dendritic cell | 8 studies | 33% ± 10% | |
non-classical monocyte | 8 studies | 24% ± 8% | |
oligodendrocyte precursor cell | 8 studies | 31% ± 8% | |
oligodendrocyte | 8 studies | 25% ± 9% | |
monocyte | 6 studies | 29% ± 13% | |
classical monocyte | 6 studies | 23% ± 8% | |
GABAergic neuron | 6 studies | 54% ± 17% | |
interneuron | 6 studies | 53% ± 20% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 8% | |
plasmacytoid dendritic cell | 5 studies | 18% ± 2% | |
conventional dendritic cell | 4 studies | 34% ± 21% | |
granule cell | 4 studies | 50% ± 21% | |
fibroblast | 4 studies | 23% ± 7% | |
astrocyte | 4 studies | 26% ± 14% | |
B cell | 3 studies | 17% ± 1% | |
GABAergic interneuron | 3 studies | 31% ± 2% | |
epithelial cell | 3 studies | 36% ± 20% | |
vein endothelial cell | 3 studies | 29% ± 18% | |
ciliated cell | 3 studies | 25% ± 8% | |
OFF-bipolar cell | 3 studies | 32% ± 9% | |
endothelial cell of vascular tree | 3 studies | 30% ± 12% | |
alveolar macrophage | 3 studies | 34% ± 9% | |
podocyte | 3 studies | 70% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2654.39 | 1444 / 1445 | 100% | 9.84 | 183 / 183 |
skin | 100% | 8201.50 | 1808 / 1809 | 100% | 27.54 | 471 / 472 |
uterus | 100% | 3424.75 | 170 / 170 | 99% | 11.52 | 456 / 459 |
breast | 100% | 3842.19 | 459 / 459 | 99% | 10.79 | 1106 / 1118 |
ovary | 100% | 3954.44 | 180 / 180 | 99% | 10.84 | 425 / 430 |
brain | 98% | 9206.36 | 2601 / 2642 | 100% | 18.29 | 705 / 705 |
lung | 100% | 4971.80 | 578 / 578 | 98% | 8.59 | 1137 / 1155 |
adrenal gland | 100% | 4388.18 | 258 / 258 | 96% | 7.14 | 221 / 230 |
thymus | 100% | 2345.57 | 650 / 653 | 95% | 5.91 | 572 / 605 |
prostate | 99% | 2412.11 | 242 / 245 | 95% | 4.66 | 476 / 502 |
bladder | 100% | 2577.24 | 21 / 21 | 93% | 7.51 | 468 / 504 |
kidney | 100% | 3639.85 | 89 / 89 | 92% | 8.31 | 831 / 901 |
intestine | 97% | 2404.82 | 936 / 966 | 85% | 4.63 | 448 / 527 |
stomach | 82% | 1478.51 | 294 / 359 | 90% | 5.59 | 257 / 286 |
pancreas | 44% | 581.25 | 144 / 328 | 98% | 9.38 | 174 / 178 |
liver | 36% | 435.55 | 82 / 226 | 78% | 3.98 | 317 / 406 |
adipose | 100% | 4882.82 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 10.26 | 29 / 29 |
spleen | 100% | 6905.10 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 9.58 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.50 | 1 / 1 |
blood vessel | 99% | 2533.38 | 1323 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 9.14 | 77 / 80 |
heart | 92% | 1610.91 | 795 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 86% | 1879.20 | 796 / 929 | 0% | 0 | 0 / 0 |
muscle | 34% | 416.89 | 270 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0003363 | Biological process | lamellipodium assembly involved in ameboidal cell migration |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0007165 | Biological process | signal transduction |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_1904861 | Biological process | excitatory synapse assembly |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0051014 | Biological process | actin filament severing |
GO_1904862 | Biological process | inhibitory synapse assembly |
GO_0060996 | Biological process | dendritic spine development |
GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
GO_0046847 | Biological process | filopodium assembly |
GO_0021816 | Biological process | extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_2001223 | Biological process | negative regulation of neuron migration |
GO_0005886 | Cellular component | plasma membrane |
GO_0005829 | Cellular component | cytosol |
GO_0045335 | Cellular component | phagocytic vesicle |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0045211 | Cellular component | postsynaptic membrane |
GO_0044327 | Cellular component | dendritic spine head |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SRGAP2 |
Protein name | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) SLIT-ROBO Rho GTPase activating protein 2 SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2 protein) SLIT-ROBO Rho GTPase-activating protein 2 |
Synonyms | FNBP2 KIAA0456 RP11-421E17.2-001 SRGAP2A RP11-421E17.2-002 ARHGAP34 RP11-421E17.2-005 |
Description | FUNCTION: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex . Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons . SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation . Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia . . |
Accessions | ENST00000604010.1 ENST00000605476.5 ENST00000419187.6 ENST00000573034.8 A0A075B7E6 A0A075B7B5 ENST00000604925.5 Q5VZB4 ENST00000624873.3 A0A1S5UZH8 O75044 ENST00000605610.5 Q5VZB5 E9PDX4 ENST00000572793.2 A0A075B743 A0A075B7E9 B7ZM87 Q5VZB3 |