CAMK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CAMK1 at tissue level.

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0051147Biological processregulation of muscle cell differentiation
GO_0007165Biological processsignal transduction
GO_0032880Biological processregulation of protein localization
GO_0051149Biological processpositive regulation of muscle cell differentiation
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0043393Biological processregulation of protein binding
GO_0060143Biological processpositive regulation of syncytium formation by plasma membrane fusion
GO_0051835Biological processpositive regulation of synapse structural plasticity
GO_0035556Biological processintracellular signal transduction
GO_0030154Biological processcell differentiation
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0006913Biological processnucleocytoplasmic transport
GO_0006468Biological processprotein phosphorylation
GO_0032091Biological processnegative regulation of protein binding
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005622Cellular componentintracellular anatomical structure
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAMK1
Protein nameCalcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
Calcium/calmodulin dependent protein kinase I
Calcium/calmodulin-dependent protein kinase I, isoform CRA_a (Calcium/calmodulin-dependent protein kinase type 1) (cDNA, FLJ95825, Homo sapiens calcium/calmodulin-dependent protein kinase I (CAMK1),mRNA)
Calcium/calmodulin-dependent protein kinase I
SynonymshCG_21548
DescriptionFUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. .

AccessionsF8W6S9
H7C071
ENST00000397277.6
ENST00000256460.8
Q14012
C9JES6
ENST00000421120.1
ENST00000411972.1
B5BU41
B0YIY3