IL20 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL20 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL20 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0045606Biological processpositive regulation of epidermal cell differentiation
GO_0050727Biological processregulation of inflammatory response
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0030316Biological processosteoclast differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0045518Molecular functioninterleukin-22 receptor binding
GO_0045517Molecular functioninterleukin-20 receptor binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL20
Protein nameInterleukin family protein
Interleukin-20 (IL-20) (Cytokine Zcyto10)
SynonymsZCYTO10
IF2D
hCG_1723949
UNQ852/PRO1801
DescriptionFUNCTION: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation . Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity . Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration . Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB . Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB . Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes . .

FUNCTION: Immune regulatory cytokine. .

AccessionsENST00000367096.7 [Q9NYY1-1]
Q9NYY1
ENST00000367098.6 [Q9NYY1-1]
ENST00000391930.3 [Q9NYY1-2]
A0A7R8C4W0