CEACAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051055Biological processnegative regulation of lipid biosynthetic process
GO_0001525Biological processangiogenesis
GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0060312Biological processregulation of blood vessel remodeling
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0032869Biological processcellular response to insulin stimulus
GO_0001558Biological processregulation of cell growth
GO_0032692Biological processnegative regulation of interleukin-1 production
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0043116Biological processnegative regulation of vascular permeability
GO_0007165Biological processsignal transduction
GO_0010594Biological processregulation of endothelial cell migration
GO_1903670Biological processregulation of sprouting angiogenesis
GO_0001915Biological processnegative regulation of T cell mediated cytotoxicity
GO_0007155Biological processcell adhesion
GO_0002682Biological processregulation of immune system process
GO_0043318Biological processnegative regulation of cytotoxic T cell degranulation
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0015721Biological processbile acid and bile salt transport
GO_1903385Biological processregulation of homophilic cell adhesion
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0002859Biological processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0045601Biological processregulation of endothelial cell differentiation
GO_0038158Biological processgranulocyte colony-stimulating factor signaling pathway
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0030334Biological processregulation of cell migration
GO_0030853Biological processnegative regulation of granulocyte differentiation
GO_2000346Biological processnegative regulation of hepatocyte proliferation
GO_0044319Biological processwound healing, spreading of cells
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0001568Biological processblood vessel development
GO_0035726Biological processcommon myeloid progenitor cell proliferation
GO_1901143Biological processinsulin catabolic process
GO_2001214Biological processpositive regulation of vasculogenesis
GO_0038016Biological processinsulin receptor internalization
GO_0016477Biological processcell migration
GO_0016324Cellular componentapical plasma membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031528Cellular componentmicrovillus membrane
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0005912Cellular componentadherens junction
GO_0070821Cellular componenttertiary granule membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0030054Cellular componentcell junction
GO_0042101Cellular componentT cell receptor complex
GO_0030658Cellular componenttransport vesicle membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0015125Molecular functionbile acid transmembrane transporter activity
GO_0031005Molecular functionfilamin binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0003779Molecular functionactin binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0005516Molecular functioncalmodulin binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCEACAM1
Protein nameCEACAM1 protein
Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
CEA cell adhesion molecule 1
SynonymsBGP
BGP1
DescriptionFUNCTION: [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis . Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils . Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 . Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 . Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation . Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA . Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). .; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). .

AccessionsM0R2K4
A0A7I2V3A7
ENST00000471298.2
ENST00000676851.1
ENST00000161559.11 [P13688-1]
ENST00000403444.7 [P13688-8]
ENST00000358394.7 [P13688-5]
ENST00000403461.5 [P13688-11]
M0R109
ENST00000352591.9 [P13688-6]
ENST00000599389.1 [P13688-9]
P13688
Q3KRG8
ENST00000600172.1