CDS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0140042Biological processlipid droplet formation
GO_0007602Biological processphototransduction
GO_0006657Biological processCDP-choline pathway
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0016024Biological processCDP-diacylglycerol biosynthetic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004142Molecular functiondiacylglycerol cholinephosphotransferase activity
GO_0004605Molecular functionphosphatidate cytidylyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDS1
Protein nameCDP-diacylglycerol synthase 1
Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1)
SynonymsCDS
DescriptionFUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol . Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs . Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis . Positively regulates the differentiation and development of adipocytes (By similarity). .

AccessionsQ92903
D6RGC8
ENST00000295887.6
ENST00000511298.1