TRIP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0007165Biological processsignal transduction
GO_0030036Biological processactin cytoskeleton organization
GO_0007154Biological processcell communication
GO_0005856Cellular componentcytoskeleton
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0001891Cellular componentphagocytic cup
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042995Cellular componentcell projection
GO_0008289Molecular functionlipid binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIP10
Protein nameThyroid hormone receptor interactor 10
Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)
SynonymshCG_23056
STOT
CIP4
STP
DescriptionFUNCTION: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. .

AccessionsM0R2H7
Q15642
M0R0F9
ENST00000596673.1
ENST00000600428.5
ENST00000596758.5
ENST00000313285.12 [Q15642-2]
ENST00000600677.5
M0R070
W4VSQ9
ENST00000313244.14 [Q15642-1]