Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 18 studies | 26% ± 11% | |
naive B cell | 13 studies | 24% ± 6% | |
CD16-positive, CD56-dim natural killer cell, human | 11 studies | 21% ± 6% | |
natural killer cell | 10 studies | 26% ± 8% | |
astrocyte | 8 studies | 26% ± 11% | |
oligodendrocyte | 8 studies | 27% ± 9% | |
type I pneumocyte | 7 studies | 25% ± 10% | |
CD16-negative, CD56-bright natural killer cell, human | 7 studies | 23% ± 4% | |
macrophage | 7 studies | 28% ± 13% | |
glutamatergic neuron | 6 studies | 26% ± 12% | |
interneuron | 6 studies | 44% ± 24% | |
type II pneumocyte | 6 studies | 33% ± 11% | |
GABAergic neuron | 6 studies | 49% ± 20% | |
pericyte | 5 studies | 29% ± 15% | |
oligodendrocyte precursor cell | 5 studies | 28% ± 10% | |
club cell | 5 studies | 24% ± 6% | |
CD8-positive, alpha-beta T cell | 4 studies | 21% ± 1% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 23% ± 7% | |
endothelial cell | 4 studies | 34% ± 9% | |
granule cell | 4 studies | 30% ± 6% | |
microglial cell | 4 studies | 20% ± 3% | |
myeloid cell | 4 studies | 23% ± 7% | |
platelet | 4 studies | 18% ± 3% | |
dendritic cell | 4 studies | 26% ± 8% | |
lymphocyte | 4 studies | 29% ± 10% | |
gamma-delta T cell | 4 studies | 21% ± 5% | |
monocyte | 4 studies | 25% ± 7% | |
fibroblast | 4 studies | 18% ± 1% | |
smooth muscle cell | 4 studies | 27% ± 5% | |
classical monocyte | 3 studies | 29% ± 8% | |
mature NK T cell | 3 studies | 24% ± 6% | |
non-classical monocyte | 3 studies | 18% ± 2% | |
GABAergic interneuron | 3 studies | 32% ± 6% | |
precursor B cell | 3 studies | 37% ± 6% | |
plasma cell | 3 studies | 26% ± 4% | |
immature B cell | 3 studies | 37% ± 11% | |
adipocyte | 3 studies | 17% ± 1% | |
cardiac muscle cell | 3 studies | 23% ± 3% | |
epithelial cell | 3 studies | 19% ± 3% | |
Mueller cell | 3 studies | 30% ± 18% | |
retinal rod cell | 3 studies | 30% ± 7% | |
megakaryocyte | 3 studies | 32% ± 6% | |
T cell | 3 studies | 20% ± 1% | |
respiratory goblet cell | 3 studies | 30% ± 12% | |
goblet cell | 3 studies | 50% ± 27% | |
neuron | 3 studies | 36% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4465.79 | 244 / 245 | 100% | 25.59 | 502 / 502 |
intestine | 100% | 5637.85 | 966 / 966 | 99% | 21.57 | 522 / 527 |
stomach | 100% | 16437.75 | 359 / 359 | 99% | 20.38 | 283 / 286 |
thymus | 100% | 5481.54 | 652 / 653 | 99% | 17.12 | 596 / 605 |
lung | 100% | 7415.86 | 577 / 578 | 97% | 17.77 | 1120 / 1155 |
breast | 99% | 3958.82 | 456 / 459 | 97% | 20.67 | 1087 / 1118 |
bladder | 100% | 3002.90 | 21 / 21 | 91% | 11.94 | 461 / 504 |
brain | 89% | 4648.12 | 2356 / 2642 | 99% | 20.53 | 701 / 705 |
adrenal gland | 97% | 2129.16 | 250 / 258 | 86% | 8.59 | 198 / 230 |
uterus | 99% | 3204.41 | 168 / 170 | 79% | 9.50 | 362 / 459 |
esophagus | 80% | 2172.97 | 1157 / 1445 | 96% | 17.24 | 176 / 183 |
skin | 78% | 1477.49 | 1410 / 1809 | 96% | 12.55 | 455 / 472 |
ovary | 100% | 5571.83 | 180 / 180 | 70% | 5.57 | 301 / 430 |
kidney | 79% | 1711.03 | 70 / 89 | 85% | 12.96 | 762 / 901 |
liver | 71% | 1190.03 | 161 / 226 | 61% | 4.88 | 248 / 406 |
pancreas | 34% | 516.46 | 111 / 328 | 96% | 11.80 | 171 / 178 |
muscle | 100% | 11652.15 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 8585.27 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6372.64 | 1330 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 3280.15 | 1195 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 8753.19 | 913 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 38.98 | 28 / 29 |
heart | 96% | 5436.59 | 824 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 7.68 | 71 / 80 |
tonsil | 0% | 0 | 0 / 0 | 87% | 8.69 | 39 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0090038 | Biological process | negative regulation of protein kinase C signaling |
GO_0006897 | Biological process | endocytosis |
GO_0007165 | Biological process | signal transduction |
GO_0046339 | Biological process | diacylglycerol metabolic process |
GO_0046834 | Biological process | lipid phosphorylation |
GO_0030168 | Biological process | platelet activation |
GO_0045742 | Biological process | positive regulation of epidermal growth factor receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006654 | Biological process | phosphatidic acid biosynthetic process |
GO_0015031 | Biological process | protein transport |
GO_2000370 | Biological process | positive regulation of clathrin-dependent endocytosis |
GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
GO_0005886 | Cellular component | plasma membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0019900 | Molecular function | kinase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0004143 | Molecular function | ATP-dependent diacylglycerol kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0019992 | Molecular function | diacylglycerol binding |
Gene name | DGKD |
Protein name | Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Uncharacterized protein DGKD Diacylglycerol kinase delta Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) |
Synonyms | KIAA0145 |
Description | FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis . . |
Accessions | Q53SV4 ENST00000430834.1 Q16760 ENST00000442524.4 ENST00000447484.5 Q53SE4 ENST00000409813.7 [Q16760-2] C9JY42 H7BZR7 H7C0L1 ENST00000427930.5 A0A096LNI6 ENST00000264057.7 [Q16760-1] |