DGKD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090038Biological processnegative regulation of protein kinase C signaling
GO_0006897Biological processendocytosis
GO_0007165Biological processsignal transduction
GO_0046339Biological processdiacylglycerol metabolic process
GO_0046834Biological processlipid phosphorylation
GO_0030168Biological processplatelet activation
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0015031Biological processprotein transport
GO_2000370Biological processpositive regulation of clathrin-dependent endocytosis
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005905Cellular componentclathrin-coated pit
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0005515Molecular functionprotein binding
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene nameDGKD
Protein nameDiacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
Uncharacterized protein DGKD
Diacylglycerol kinase delta
Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta)
SynonymsKIAA0145
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis . .

AccessionsQ53SV4
ENST00000430834.1
Q16760
ENST00000442524.4
ENST00000447484.5
Q53SE4
ENST00000409813.7 [Q16760-2]
C9JY42
H7BZR7
H7C0L1
ENST00000427930.5
A0A096LNI6
ENST00000264057.7 [Q16760-1]