GRP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRP at tissue level.

III. Associated gene sets

GO_1905461Biological processpositive regulation of vascular associated smooth muscle cell apoptotic process
GO_0010468Biological processregulation of gene expression
GO_0007218Biological processneuropeptide signaling pathway
GO_1903817Biological processnegative regulation of voltage-gated potassium channel activity
GO_1904384Biological processcellular response to sodium phosphate
GO_1905151Biological processnegative regulation of voltage-gated sodium channel activity
GO_0007165Biological processsignal transduction
GO_2000987Biological processpositive regulation of behavioral fear response
GO_0090277Biological processpositive regulation of peptide hormone secretion
GO_0036343Biological processpsychomotor behavior
GO_1903942Biological processpositive regulation of respiratory gaseous exchange
GO_0043303Biological processmast cell degranulation
GO_0043207Biological processresponse to external biotic stimulus
GO_1900738Biological processpositive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0001503Biological processossification
GO_0035176Biological processsocial behavior
GO_0098992Cellular componentneuronal dense core vesicle
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043005Cellular componentneuron projection
GO_0034774Cellular componentsecretory granule lumen
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameGRP
Protein nameGRP protein
Gastrin-releasing peptide
Unique cartilage matrix-associated protein
Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)]
Gastrin releasing peptide
SynonymsUCMA
DescriptionFUNCTION: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). .; FUNCTION: [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. .

FUNCTION: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. .

FUNCTION: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. .

FUNCTION: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. .

FUNCTION: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. .

FUNCTION: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. .

AccessionsA0A067XJX6
Q5FBX9
H0Y5C5
P07492
A0A067XKV3
H0YCH3
A0A067XJP8
ENST00000256857.7 [P07492-1]
ENST00000529320.2 [P07492-2]
Q6LDX5
ENST00000530323.1
ENST00000456142.3
ENST00000420468.6 [P07492-3]