FNBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	39% ± 11%	Explore
natural killer cell	39 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	38 studies	35% ± 12%	Explore
macrophage	37 studies	37% ± 18%	Explore
T cell	35 studies	38% ± 13%	Explore
CD4-positive, alpha-beta T cell	33 studies	36% ± 11%	Explore
regulatory T cell	28 studies	37% ± 12%	Explore
endothelial cell	27 studies	32% ± 13%	Explore
dendritic cell	26 studies	49% ± 24%	Explore
conventional dendritic cell	24 studies	36% ± 11%	Explore
classical monocyte	23 studies	28% ± 11%	Explore
mature NK T cell	20 studies	34% ± 10%	Explore
memory B cell	20 studies	39% ± 11%	Explore
astrocyte	20 studies	57% ± 22%	Explore
monocyte	18 studies	33% ± 14%	Explore
naive B cell	18 studies	31% ± 9%	Explore
smooth muscle cell	18 studies	33% ± 12%	Explore
gamma-delta T cell	18 studies	39% ± 15%	Explore
non-classical monocyte	17 studies	30% ± 13%	Explore
oligodendrocyte	17 studies	63% ± 20%	Explore
myeloid cell	17 studies	36% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	35% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	34% ± 11%	Explore
fibroblast	15 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 10%	Explore
mucosal invariant T cell	14 studies	39% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	35% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	42% ± 13%	Explore
leukocyte	13 studies	42% ± 18%	Explore
plasmacytoid dendritic cell	13 studies	32% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	33% ± 9%	Explore
microglial cell	12 studies	34% ± 11%	Explore
mast cell	11 studies	27% ± 13%	Explore
GABAergic neuron	11 studies	43% ± 21%	Explore
glutamatergic neuron	11 studies	43% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	47% ± 12%	Explore
pericyte	11 studies	27% ± 13%	Explore
plasma cell	11 studies	28% ± 9%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 10%	Explore
innate lymphoid cell	9 studies	38% ± 12%	Explore
myofibroblast cell	8 studies	33% ± 17%	Explore
T follicular helper cell	8 studies	39% ± 9%	Explore
epithelial cell	8 studies	35% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 9%	Explore
mononuclear phagocyte	7 studies	40% ± 12%	Explore
neuron	7 studies	43% ± 19%	Explore
interneuron	7 studies	46% ± 19%	Explore
ciliated cell	7 studies	25% ± 10%	Explore
CD4-positive helper T cell	6 studies	36% ± 18%	Explore
hematopoietic precursor cell	6 studies	39% ± 14%	Explore
capillary endothelial cell	6 studies	23% ± 6%	Explore
endothelial cell of artery	6 studies	29% ± 14%	Explore
hematopoietic stem cell	6 studies	38% ± 18%	Explore
Mueller cell	6 studies	38% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	42% ± 14%	Explore
connective tissue cell	6 studies	22% ± 5%	Explore
exhausted T cell	5 studies	36% ± 10%	Explore
plasmablast	5 studies	31% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	36% ± 11%	Explore
retinal ganglion cell	5 studies	26% ± 6%	Explore
lymphocyte	5 studies	57% ± 22%	Explore
pro-B cell	5 studies	31% ± 11%	Explore
immature B cell	5 studies	32% ± 14%	Explore
retina horizontal cell	5 studies	20% ± 4%	Explore
endothelial cell of vascular tree	5 studies	24% ± 14%	Explore
endothelial cell of lymphatic vessel	5 studies	26% ± 5%	Explore
club cell	5 studies	24% ± 5%	Explore
basal cell	5 studies	26% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	33% ± 16%	Explore
glial cell	4 studies	27% ± 9%	Explore
granule cell	4 studies	51% ± 17%	Explore
progenitor cell	4 studies	26% ± 5%	Explore
precursor B cell	4 studies	27% ± 10%	Explore
amacrine cell	4 studies	20% ± 5%	Explore
retinal pigment epithelial cell	4 studies	44% ± 14%	Explore
abnormal cell	4 studies	30% ± 10%	Explore
alveolar macrophage	4 studies	43% ± 18%	Explore
type I pneumocyte	4 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	4 studies	57% ± 11%	Explore
T-helper 1 cell	4 studies	45% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	32% ± 16%	Explore
double negative thymocyte	4 studies	44% ± 18%	Explore
glomerular endothelial cell	3 studies	25% ± 5%	Explore
podocyte	3 studies	30% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	40% ± 16%	Explore
GABAergic interneuron	3 studies	40% ± 6%	Explore
common myeloid progenitor	3 studies	29% ± 18%	Explore
mesothelial cell	3 studies	36% ± 11%	Explore
tissue-resident macrophage	3 studies	44% ± 18%	Explore
GABAergic amacrine cell	3 studies	26% ± 6%	Explore
retinal rod cell	3 studies	20% ± 3%	Explore
germinal center B cell	3 studies	49% ± 3%	Explore
IgA plasma cell	3 studies	28% ± 12%	Explore
inflammatory macrophage	3 studies	34% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	40% ± 15%	Explore
muscle cell	3 studies	38% ± 27%	Explore
neural progenitor cell	3 studies	31% ± 13%	Explore
ependymal cell	3 studies	48% ± 16%	Explore
granulocyte monocyte progenitor cell	3 studies	32% ± 9%	Explore
neutrophil	3 studies	32% ± 15%	Explore
T-helper 17 cell	3 studies	54% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	24% ± 5%	Explore
mural cell	3 studies	40% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	45% ± 19%	Explore
peripheral blood	16 studies	33% ± 12%	Explore
lung	13 studies	25% ± 7%	Explore
eye	5 studies	27% ± 15%	Explore
bone marrow	4 studies	33% ± 11%	Explore
intestine	4 studies	26% ± 6%	Explore
uterus	4 studies	23% ± 10%	Explore
breast	4 studies	16% ± 1%	Explore
liver	4 studies	33% ± 12%	Explore
adipose	4 studies	27% ± 7%	Explore
heart	3 studies	21% ± 4%	Explore
kidney	3 studies	27% ± 4%	Explore
skin	3 studies	19% ± 1%	Explore
lymph node	3 studies	37% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	10713.16	244 / 245	100%	44.66	502 / 502
brain	100%	10955.31	2631 / 2642	100%	46.41	705 / 705
thymus	99%	8119.79	649 / 653	100%	52.70	603 / 605
ovary	99%	4946.39	179 / 180	100%	36.45	428 / 430
skin	99%	4935.38	1799 / 1809	99%	35.91	467 / 472
uterus	100%	11063.40	170 / 170	97%	26.48	443 / 459
lung	99%	5829.53	570 / 578	97%	27.03	1123 / 1155
bladder	100%	16839.76	21 / 21	95%	20.85	480 / 504
breast	96%	3847.90	439 / 459	99%	34.49	1111 / 1118
esophagus	100%	20570.85	1443 / 1445	93%	25.25	170 / 183
intestine	99%	17758.10	961 / 966	90%	18.48	475 / 527
kidney	88%	3131.98	78 / 89	96%	25.21	868 / 901
adrenal gland	73%	2148.80	188 / 258	91%	16.04	210 / 230
stomach	67%	5876.62	241 / 359	91%	26.39	260 / 286
liver	22%	577.00	49 / 226	92%	15.25	375 / 406
pancreas	3%	81.20	10 / 328	97%	23.50	173 / 178
eye	0%	0	0 / 0	100%	74.07	80 / 80
lymph node	0%	0	0 / 0	100%	177.78	29 / 29
spleen	100%	11490.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.68	45 / 45
blood vessel	100%	7310.75	1332 / 1335	0%	0	0 / 0
adipose	98%	4682.70	1175 / 1204	0%	0	0 / 0
peripheral blood	95%	17915.32	883 / 929	0%	0	0 / 0
muscle	67%	2103.28	537 / 803	0%	0	0 / 0
heart	45%	1293.39	391 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0006897	Biological process	endocytosis
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005905	Cellular component	clathrin-coated pit
GO_0005764	Cellular component	lysosome
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0008289	Molecular function	lipid binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FNBP1
Protein name	Formin binding protein 1 Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) FNBP1 protein
Synonyms	FBP17 KIAA0554
Description	FUNCTION: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. .
Accessions	ENST00000449089.7 ENST00000355681.3 [Q96RU3-3] A0A8V8TQ35 ENST00000699492.1 ENST00000703558.1 A0A994J3V8 ENST00000703560.1 H0Y7W6 ENST00000446176.7 [Q96RU3-1] B7ZL13 ENST00000703559.1 A0A994J3U5 B7ZL14 ENST00000703532.1 [Q96RU3-2] A0A994J6U4 Q96RU3 ENST00000703533.1 A0A994J4A3

FNBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review