SHOC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	26 studies	24% ± 6%	Explore
endothelial cell	23 studies	27% ± 10%	Explore
classical monocyte	20 studies	24% ± 7%	Explore
monocyte	17 studies	24% ± 8%	Explore
memory B cell	16 studies	22% ± 5%	Explore
naive B cell	15 studies	22% ± 4%	Explore
non-classical monocyte	15 studies	26% ± 9%	Explore
ciliated cell	12 studies	24% ± 9%	Explore
macrophage	11 studies	27% ± 7%	Explore
endothelial cell of lymphatic vessel	10 studies	22% ± 4%	Explore
microglial cell	10 studies	25% ± 9%	Explore
natural killer cell	9 studies	19% ± 3%	Explore
glutamatergic neuron	9 studies	40% ± 23%	Explore
fibroblast	9 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	9 studies	21% ± 9%	Explore
myeloid cell	8 studies	23% ± 9%	Explore
adipocyte	8 studies	25% ± 6%	Explore
GABAergic neuron	8 studies	34% ± 20%	Explore
astrocyte	8 studies	28% ± 13%	Explore
oligodendrocyte	8 studies	25% ± 7%	Explore
endothelial cell of artery	7 studies	18% ± 3%	Explore
epithelial cell	7 studies	33% ± 16%	Explore
smooth muscle cell	7 studies	17% ± 1%	Explore
pericyte	7 studies	20% ± 6%	Explore
mast cell	6 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	16% ± 1%	Explore
interneuron	6 studies	34% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 2%	Explore
regulatory T cell	6 studies	18% ± 3%	Explore
T cell	5 studies	21% ± 6%	Explore
neutrophil	5 studies	21% ± 5%	Explore
capillary endothelial cell	5 studies	18% ± 2%	Explore
neuron	5 studies	30% ± 9%	Explore
precursor B cell	5 studies	38% ± 8%	Explore
pro-B cell	5 studies	26% ± 6%	Explore
dendritic cell	5 studies	33% ± 13%	Explore
vein endothelial cell	5 studies	21% ± 10%	Explore
type I pneumocyte	5 studies	20% ± 3%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 10%	Explore
gamma-delta T cell	5 studies	21% ± 4%	Explore
leukocyte	4 studies	20% ± 2%	Explore
CD4-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
basal cell	4 studies	29% ± 8%	Explore
immature B cell	4 studies	26% ± 7%	Explore
retina horizontal cell	4 studies	24% ± 6%	Explore
lymphocyte	4 studies	23% ± 6%	Explore
endothelial cell of vascular tree	4 studies	23% ± 11%	Explore
type II pneumocyte	4 studies	18% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	16% ± 0%	Explore
conventional dendritic cell	3 studies	31% ± 8%	Explore
hematopoietic precursor cell	3 studies	33% ± 14%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
GABAergic interneuron	3 studies	19% ± 4%	Explore
retinal ganglion cell	3 studies	46% ± 15%	Explore
club cell	3 studies	20% ± 3%	Explore
retinal cone cell	3 studies	30% ± 3%	Explore
retinal rod cell	3 studies	19% ± 2%	Explore
mononuclear phagocyte	3 studies	23% ± 6%	Explore
Mueller cell	3 studies	17% ± 2%	Explore
germinal center B cell	3 studies	21% ± 4%	Explore
mature NK T cell	3 studies	16% ± 1%	Explore
hepatocyte	3 studies	27% ± 16%	Explore
mucosal invariant T cell	3 studies	17% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	33% ± 17%	Explore
peripheral blood	10 studies	22% ± 6%	Explore
lung	7 studies	22% ± 6%	Explore
eye	4 studies	25% ± 6%	Explore
adipose	4 studies	20% ± 3%	Explore
liver	3 studies	25% ± 7%	Explore
bone marrow	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2608.25	1445 / 1445	100%	42.27	183 / 183
uterus	100%	2609.76	170 / 170	100%	31.76	459 / 459
breast	100%	3126.37	459 / 459	100%	65.09	1117 / 1118
ovary	100%	2096.24	180 / 180	100%	26.27	429 / 430
brain	100%	2290.29	2635 / 2642	100%	31.90	705 / 705
thymus	100%	2582.02	653 / 653	100%	43.76	603 / 605
lung	100%	2387.03	576 / 578	100%	36.82	1155 / 1155
prostate	100%	2128.47	244 / 245	100%	39.22	502 / 502
kidney	100%	1671.18	89 / 89	99%	36.74	895 / 901
bladder	100%	2574.90	21 / 21	99%	30.13	500 / 504
adrenal gland	100%	1888.47	258 / 258	99%	42.11	228 / 230
pancreas	99%	1282.91	325 / 328	99%	37.20	177 / 178
stomach	100%	1783.23	359 / 359	98%	33.86	280 / 286
intestine	100%	2628.38	966 / 966	98%	31.73	514 / 527
liver	100%	1237.27	226 / 226	96%	19.75	391 / 406
skin	100%	3109.53	1809 / 1809	94%	29.29	446 / 472
blood vessel	100%	3128.64	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	52.13	29 / 29
muscle	100%	2246.07	803 / 803	0%	0	0 / 0
spleen	100%	2179.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.81	45 / 45
ureter	0%	0	0 / 0	100%	16.38	1 / 1
adipose	100%	3758.89	1203 / 1204	0%	0	0 / 0
heart	97%	1550.54	837 / 861	0%	0	0 / 0
peripheral blood	97%	3514.05	898 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	91%	20.62	73 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007265	Biological process	Ras protein signal transduction
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007165	Biological process	signal transduction
GO_0038180	Biological process	nerve growth factor signaling pathway
GO_0140361	Biological process	cyclic-GMP-AMP transmembrane import across plasma membrane
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0071378	Biological process	cellular response to growth hormone stimulus
GO_0046579	Biological process	positive regulation of Ras protein signal transduction
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_2000178	Biological process	negative regulation of neural precursor cell proliferation
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0000164	Cellular component	protein phosphatase type 1 complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019903	Molecular function	protein phosphatase binding
GO_0008157	Molecular function	protein phosphatase 1 binding
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SHOC2
Protein name	Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) SHOC2 leucine rich repeat scaffold protein (Soc-2 suppressor of clear homolog (C. elegans), isoform CRA_b) SHOC2 leucine rich repeat scaffold protein
Synonyms	hCG_40725 KIAA0862
Description	FUNCTION: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. .
Accessions	A0A8I5KUQ6 ENST00000369452.9 [Q9UQ13-1] A0A8I5KUD9 ENST00000691369.1 [Q9UQ13-1] ENST00000689118.1 [Q9UQ13-1] ENST00000692776.1 ENST00000688928.1 [Q9UQ13-1] ENST00000689300.1 [Q9UQ13-1] ENST00000265277.10 [Q9UQ13-2] X6RI37 ENST00000451838.2 A0A8I5QJS4 ENST00000685613.1 Q9UQ13 ENST00000691441.1 [Q9UQ13-1] ENST00000691903.1 ENST00000685059.1 [Q9UQ13-1] ENST00000689997.1

SHOC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review